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Vol. 80, No. 5-6, 2011
Issue release date: August 2011
Section title: Clinical Study
Oncology 2011;80:366–372
(DOI:10.1159/000330549)

Occurrence of Hepatocellular Carcinoma Was Not a Rare Event during and Immediately after Antiviral Treatment in Japanese HCV-Positive Patients

Kanda T. · Imazeki F. · Mikami S. · Kato K. · Shimada N. · Yonemitsu Y. · Miyauchi T. · Arai M. · Fujiwara K. · Tsubota A. · Takada N. · Nishino T. · Takashi M. · Sugiura N. · Kimura M. · Fukai K. · Yokosuka O.
aDepartment of Medicine and Clinical Oncology, Chiba University, Graduate School of Medicine, Chiba, bKikkoman Hospital, Noda, cNarita Red Cross Hospital, Narita, dShin-Matsudo Central General Hospital, Matsudo, eInstitute of Clinical Medicine and Research, Jikei University School of Medicine, Kashiwa, fToho University Sakura Medical Center, Sakura, gTokyo Women’s Medical University Yachiyo Medical Center, Yachiyo, hSaiseikai Narashino Hospital, Narashino, iNational Hospital Organization Chiba Medical Center, Chiba, and jSocial Insurance Funabashi Central Hospital, Funabashi, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/21/2011 1:16:56 PM
Accepted: 6/2/2011
Published online: 8/3/2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Advanced chronic hepatitis C patients with sustained virolological response by antivirals remain at risk for hepatocellular carcinoma (HCC). We investigated the incidence of HCC during and immediately after peginterferon-alfa-2a and ribavirin (RBV) treatment in patients with chronic hepatitis C in Japan. HCC was detected in 8 of 238 patients during and after these treatments (mean follow-up period: 572 ± 252 days). In conclusion, occurrence of HCC is not a rare event during and immediately after peginterferon-alfa-2a plus RBV treatment. In cases with cirrhosis, higher α-fetoprotein levels, old age, or a previous history of HCC treatment, clinicians should be especially alert for the possible development of HCC during and immediately after peginterferon-alfa-2a and RBV treatment. Clinicians should regularly check for the possible development of HCC even in chronic hepatitis C patients under treatment.


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/21/2011 1:16:56 PM
Accepted: 6/2/2011
Published online: 8/3/2011

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Di Bisceglie AM: Hepatitis C and hepatocellular carcinoma. Hepatology 1997;26:34S–38S.
  2. Grant WC, Jhaveri RR, McHutchison JG, Schulman KA, Kauf TL: Trends in health care resource use for hepatitis C virus infection in the United States. Hepatology 2005;42:1406–1413.

    External Resources

  3. Kanda T, Yokosuka O, Nagao K, Saisho H: State of hepatitis C viral replication enhances activation of NF-kb- and ap-1-signaling induced by hepatitis B virus X. Cancer Lett 2006;234:143–148.
  4. Kanda T, Imazeki F, Yokosuka O: New antiviral therapies for chronic hepatitis C. Hepatol Int 2010;4:548–561.

    External Resources

  5. Zhang CH, Xu GL, Jia WD, Li JS, Ma JL, Ge YS: Effects of interferon treatment on development and progression of hepatocellular carcinoma in patients with chronic virus infection: a meta-analysis of randomized controlled trials. Int J Cancer 2011;129:1254–1264.
  6. Imazeki F, Yokosuka O, Fukai K, Saisho H: Favorable prognosis of chronic hepatitis C after interferon therapy by long-term cohort study. Hepatology 2003;38:493–502.
  7. Cardoso AC, Moucari R, Figueiredo-Mendes C, Ripault MP, Giuily N, Castelnau C, Boyer N, Asselah T, Martinot-Peignoux M, Maylin S, Carvalho-Filho RJ, Valla D, Bedossa P, Marcellin P: Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis. J Hepatol 2010;52:652–657.
  8. Singal AK, Singh A, Jaganmohan S, Guturu P, Mummadi R, Kuo YF, Sood GK: Antiviral therapy reduces risk of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis. Clin Gastroenterol Hepatol 2010;8:192–199.

    External Resources

  9. Morgan TR, Ghany MG, Kim HY, Snow KK, Shiffman ML, De Santo JL, Lee WM, Di Bisceglie AM, Bonkovsky HL, Dienstag JL, Morishima C, Lindsay KL, Lok AS: Outcome of sustained virological responders with histologically advanced chronic hepatitis C. Hepatology 2010;52:833–844.
  10. Noureddin M, Ghany MG: Editorial: Treatment of patients with HCV-related cirrhosis with peginterferon and ribavirin: swinging the pendulum toward treatment. Am J Gastroenterol 2010;105:2174–2176.

    External Resources

  11. Craxi A, Camma C: Does chemotherapy prevent HCV-related hepatocellular carcinoma? Cons. Dig Liver Dis 2010;42 Suppl 3:S287–S292.

    External Resources

  12. George SL, Bacon BR, Brunt EM, Mihindukulasuriya KL, Hoffmann J, Di Bisceglie AM: Clinical, virologic, histologic, and biochemical outcomes after successful HCV therapy: a 5-year follow-up of 150 patients. Hepatology 2009;49:729–738.
  13. Vukotic R, Gramenzi A, Vitale G, Cursaro C, Serra C, Biselli M, Scuteri A, Andreone P, Bernardi M: Hepatocellular carcinoma appearance in patients with hepatitis C virus-related chronic liver disease 90 and 70 months after sustained virological response to interferon and ribavirin. Liver Int 2008;28:407–411.
  14. Nakamoto S, Kanda T, Imazeki F, Wu S, Arai M, Fujiwara K, Yokosuka O: Simple assay based on restriction fragment length polymorphism associated with IL28B in chronic hepatitis C patients. Scand J Gastroenterol 2011;46:955–961.
  15. Kanda T, Imazeki F, Yonemitsu Y, Mikami S, Takada N, Nishino T, Takashi M, Tsubota A, Kato K, Sugiura N, Tawada A, Wu S, Tanaka T, Nakamoto S, Mikata R, Tada M, Chiba T, Kurihara T, Arai M, Fujiwara K, Kanai F, Yokosuka O: Quantification of hepatitis C virus in patients treated with peginterferon-alfa-2a plus ribavirin treatment by COBAS TaqMan HCV test. J Viral Hepat 2011;18:e292–e297.

    External Resources

  16. Yu ML, Lin SM, Chuang WL, Dai CY, Wang JH, Lu SN, Sheen IS, Chang WY, Lee CM, Liaw YF: A sustained virological response to interferon or interferon/ribavirin reduces hepatocellular carcinoma and improves survival in chronic hepatitis C: a nationwide, multicentre study in Taiwan. Antivir Ther 2006;11:985–994.
  17. Sato T, Tateishi R, Yoshida H, Ohki T, Masuzaki R, Imamura J, Goto T, Kanai F, Obi S, Kato N, Shiina S, Kawabe T, Omata M: Ultrasound surveillance for early detection of hepatocellular carcinoma among patients with chronic hepatitis C. Hepatol Int 2009;3:544–550.

    External Resources

  18. Nakamoto S, Imazeki F, Fukai K, Fujiwara K, Arai M, Kanda T, Yonemitsu Y, Yokosuka O: Association between mutations in the core region of hepatitis C virus genotype 1 and hepatocellular carcinoma development. J Hepatol 2010;52:72–78.
  19. Kainuma M, Furusyo N, Kajiwara E, Takahashi K, Nomura H, Tanabe Y, Satoh T, Maruyama T, Nakamuta M, Kotoh K, Azuma K, Shimono J, Shimoda S, Hayashi J: Pegylated interferon alpha-2b plus ribavirin for older patients with chronic hepatitis C. World J Gastroenterol 2010;16:4400–4409.
  20. Thomas DL, Thio CL, Martin MP, Qi Y, Ge D, O’Huigin C, Kidd J, Kidd K, Khakoo SI, Alexander G, Goedert JJ, Kirk GD, Donfield SM, Rosen HR, Tobler LH, Busch MP, McHutchison JG, Goldstein DB, Carrington M: Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 2009;461:798–801.
  21. Di Bisceglie AM, Shiffman ML, Everson GT, Lindsay KL, Everhart JE, Wright EC, Lee WM, Lok AS, Bonkovsky HL, Morgan TR, Ghany MG, Morishima C, Snow KK, Dienstag JL: Prolonged therapy of advanced chronic hepatitis C with low-dose peginterferon. N Engl J Med 2008;359:2429–2441.
  22. Yuen MF, Hou JL, Chutaputti A: Hepatocellular carcinoma in the Asia Pacific region. J Gastroenterol Hepatol 2009;24:346–353.
  23. Yoshida H, Shiratori Y, Moriyama M, Arakawa Y, Ide T, Sata M, Inoue O, Yano M, Tanaka M, Fujiyama S, Nishiguchi S, Kuroki T, Imazeki F, Yokosuka O, Kinoyama S, Yamada G, Omata M: Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan: IHIT study group – inhibition of hepatocarcinogenesis by interferon therapy. Ann Intern Med 1999;131:174–181.
  24. Imazeki F, Yokosuka O, Fukai K, Hiraide A, Saisho H: Significance of prior hepatitis B virus infection in the development of hepatocellular carcinoma in patients with chronic hepatitis C. Dig Dis Sci 2003;9:1789–1792.
  25. Sugiura N, Sakai Y, Ebara M, Fukuda H, Yoshikawa M, Saisho H, Ohto M, Kondo F: Detection of hepatocellular carcinoma after interferon therapy for chronic hepatitis C: clinical study of 26 cases. J Gastroenterol Hepatol 1996;11:535–539.
  26. Gane E: Future hepatitis C virus treatment: interferon-sparing combinations. Liver Int 2011;31(suppl 1):62–67.

    External Resources

  27. Ito Y, Yamamoto N, Nakata R, Kato Y, Iori M, Sakai K, Takemura T, Tateishi R, Yoshida H, Kawabe T, Omata M: Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy. World J Gastroenterol 2005;11:7218–7221.

    External Resources