Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 35, No. 2, 2012
Issue release date: March 2012
Section title: Original Paper
Free Access
Kidney Blood Press Res 2012;35:106–113
(DOI:10.1159/000330716)

Serum Vitamin D Level and Prehypertension among Subjects Free of Hypertension

· Sabanayagam C.a · Shankar A.a · Somasundaram S.b
aDepartment of Community Medicine, West Virginia University School of Medicine, Morgantown, W. Va., USA; bDepartment of Cardiology, KS Hospital, Chennai, India
email Corresponding Author

Dr. Anoop Shankar

Department of Medicine, West Virginia University School of Medicine

PO Box 9190

Morgantown, WV 26506-9190 (USA)

Tel. +1 304 293 0199, E-Mail ashankar@hsc.wvu.edu


References

  1. Lee JH, O’Keefe JH, Bell D, Hensrud DD, Holick MF: Vitamin D Deficiency: An important, common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008;52:1949–1956.
  2. Baz-Hecht M, Goldfine AB: The impact of vitamin D deficiency on diabetes and cardiovascular risk. Curr Opin Endocrinol Diabetes Obes 2010;17:113–119.
  3. Wang TJ, Pencina MJ, Booth SL, et al: Vitamin D deficiency and risk of cardiovascular disease. Circulation 2008;117:503–511.
  4. Forman JP, Curhan GC, Taylor EN: Plasma 25-hydroxyvitamin D levels and risk of incident hypertension among young women. Hypertension 2008;52:828–832.
  5. Forman JP, Giovannucci E, Holmes MD, et al: Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 2007;49:1063–1069.
  6. Judd SE, Nanes MS, Ziegler TR, Wilson PW, Tangpricha V: Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the Third National Health and Nutrition Examination Survey. Am J Clin Nutr 2008;87:136–141.
  7. Schmitz KJ, Skinner HG, Bautista LE, et al: Association of 25-hydroxyvitamin D with blood pressure in predominantly 25-hydroxyvitamin D deficient Hispanic and African Americans. Am J Hypertens 2009;22:867–870.
  8. Scragg R, Sowers M, Bell C: Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey. Am J Hypertens 2007;20:713–719.
  9. Zhao G, Ford ES, Li C, Kris-Etherton PM, Etherton TD, Balluz LS: Independent associations of serum concentrations of 25-hydroxyvitamin D and parathyroid hormone with blood pressure among US adults. J Hypertens 2010;28:1821–1828.
  10. Gupta AK, Brashear MM, Johnson WD: Prediabetes and prehypertension in healthy adults are associated with low vitamin D levels. Diabetes Care 2011;34:658–660.
  11. Chonchol M, Scragg R: 25-Hydroxyvitamin D, insulin resistance, and kidney function in the Third National Health and Nutrition Examination Survey. Kidney Int 2007;71:134–139.
  12. Barri YM: Hypertension and kidney disease: a deadly connection. Curr Cardiol Rep 2006;8:411–417.
  13. Sesso HD, Buring JE, Rifai N, Blake GJ, Gaziano JM, Ridker PM: C-Reactive protein and the risk of developing hypertension. JAMA 2003;290:2945–2951.
  14. Nagpal S, Na S, Rathnachalam R: Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 2005;26:662–687.
  15. Forouhi NG, Luan J, Cooper A, Boucher BJ, Wareham NJ: Baseline serum 25-hydroxy vitamin D is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990–2000. Diabetes 2008;57:2619–2625.
  16. Jorde R, Figenschau Y, Emaus N, Hutchinson M, Grimnes G: Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension. Hypertension 2010;55:792–798.
  17. Chobanian AV, Bakris GL, Black HR, et al: The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003;289:2560–2572.
  18. Liszka HA, Mainous AG, III, King DE, Everett CJ, Egan BM: Prehypertension and cardiovascular morbidity. Ann Fam Med 2005;3:294–299.
  19. Vasan RS, Larson MG, Leip EP, et al: Impact of high-normal blood pressure on the risk of cardiovascular disease. N Engl J Med 2001;345:1291–1297.
  20. Gupta AK, McGlone M, Greenway FL, Johnson WD: Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile. Hypertens Res 2010;33:905–910.
  21. Vasan RS, Larson MG, Leip EP, Kannel WB, Levy D: Assessment of frequency of progression to hypertension in non-hypertensive participants in the Framingham Heart Study: a cohort study. Lancet 2001;358:1682–1686.
  22. National Center for Health Statistics: The Third National Health and Nutrition Examination Survey: reference manuals and reports [article online]. Available at: www.cdc.gov/nchs/data/nhanes/nh3rrm.htm [accessed April 29, 2010] 1996.
  23. National Center for Health Statistics: Analytic and reporting guidelines: NHANES III [article online]. Available at: www.cdc.gov/nchs/data/nhanes/nhanes3/nh3gui.pdf [accessed April 29, 2010] 1996.
  24. Perloff D, Grim C, Flack J, et al: Human blood pressure determination by sphygmomanometry. Circulation 1993;88:2460–2470.
  25. National Center for Health Statistics: Laboratory procedures used for NHANES III. Available at: www.cdc.gov/nchs/data/nhanes/nhanes3/cdrom/nchs/manuals/labman.pdf [accessed April 29, 2010] 1996.
  26. Expert Committee on the Diagnosis of Diabetes Mellitus: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 2003;26(suppl 1):S5–S20.
    External Resources
  27. Haddad JG Jr, Hahn TJ: Natural and synthetic sources of circulating 25-hydroxyvitamin D in man. Nature 1973;244:515–517.
  28. Hintzpeter B, Mensink GB, Thierfelder W, Muller MJ, Scheidt-Nave C: Vitamin D status and health correlates among German adults. Eur J Clin Nutr 2008;62:1079–1089.
  29. Hypponen E, Boucher BJ, Berry DJ, Power C: 25-hydroxyvitamin D, IGF-1, and metabolic syndrome at 45 years of age: a cross-sectional study in the 1958 British Birth Cohort. Diabetes 2008;57:298–305.
  30. Lee DM, Rutter MK, O’Neill TW, et al: Vitamin D, parathyroid hormone and the metabolic syndrome in middle-aged and older European men. Eur J Endocrinol 2009;161:947–954.
  31. Jorde R, Figenschau Y, Emaus N, Hutchinson M, Grimnes G: Serum 25-hydroxyvitamin D levels are strongly related to systolic blood pressure but do not predict future hypertension. Hypertension 2010;55:792–798.
  32. Margolis KL, Ray RM, Van Horn L, et al: Effect of calcium and vitamin D supplementation on blood pressure: the Women’s Health Initiative Randomized Trial. Hypertension 2008;52:847–855.
  33. Jorde R, Sneve M, Torjesen P, Figenschau Y: No improvement in cardiovascular risk factors in overweight and obese subjects after supplementation with vitamin D3 for 1 year. J Intern Med 2010;267:462–472.
  34. Li YC, Kong J, Wei M, Chen ZF, Liu SQ, Cao LP: 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. J Clin Invest 2002;110:229–238.
  35. Simpson RU, Hershey SH, Nibbelink KA: Characterization of heart size and blood pressure in the vitamin D receptor knockout mouse. J Steroid Biochem Mol Biol 2007;103:521–524.
  36. Pittas AG, Lau J, Hu FB, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017–2029.
  37. Talmor Y, Golan E, Benchetrit S, et al: Calcitriol blunts the deleterious impact of advanced glycation end products on endothelial cells. Am J Physiol Renal Physiol 2008;294:F1059–F1064.
  38. Talmor Y, Bernheim J, Klein O, Green J, Rashid G: Calcitriol blunts pro-atherosclerotic parameters through NFkappaB and p38 in vitro. Eur J Clin Invest 2008;38:548–554.
  39. Freundlich M, Quiroz Y, Zhang Z, et al: Suppression of renin-angiotensin gene expression in the kidney by paricalcitol. Kidney Int 2008;74:1394–1402.
  40. Bodnar LM, Catov JM, Simhan HN, Holick MF, Powers RW, Roberts JM: Maternal vitamin D deficiency increases the risk of preeclampsia. J Clin Endocrinol Metab 2007;92:3517–3522.