Objective: To analyze mid-term neurodevelopment outcome in children with isolated mild ventriculomegaly (VM) ≤12 mm diagnosed in fetal life, using the Battelle Developmental Inventory Screening Test (BDIST). Methods: 86 cases of mild VM were identified. 68 were excluded due to: other cerebral anomalies (n = 40), extra-cerebral anomalies (n = 3), chromosomal defects (n = 4), dysmorphic syndromes (n = 4), congenital infections (n = 2), termination of pregnancy (n = 9), stillbirth (n = 2) and incomplete follow-up (n = 4). 18 cases (range 1-8 years) of isolated mild VM were included for analysis. Seven neurodevelopment domains were assessed by BDIST. Results: Routine neuropediatrical evaluation detected neurological disorders in five children (28%; 3 with language impairment, one left hemiparesis and one intellectual retardation). BDIST showed some degree of neurodevelopmental delay in higher proportions: 66% in social-personal skills, 56% in gross motor skills, 39% in adaptive behavior and 28% in fine motor skills. Communicative and cognitive areas were the least affected (11 and 22% had moderate-to-severe involvement, respectively). A general trend towards worse outcomes was observed in the group of ≧4 years, although significant differences were only found for gross motor skills. Conclusion: Subtle neurological delays may appear during the infant period in fetuses prenatally diagnosed of isolated mild VM. In consequence, adequate measures should be established for early detection and treatment.
© 2011 S. Karger AG, Basel
- Fetal mild ventriculomegaly
- Neurodevelopmental outcome
- Prenatal diagnosis
- Battelle Developmental Inventory Screening Test
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Dr. A. Galindo
Fetal Medicine Unit
Department of Obstetrics and Gynecology, Hospital Universitario ‘12 de Octubre'
Avenida de Córdoba s/n, ES-28041 Madrid (Spain)
Tel. +34 913 908 310, E-Mail firstname.lastname@example.org
Received: June 22, 2011
Accepted after revision: July 27, 2011
Published online: December 14, 2011
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 29
Fetal Diagnosis and Therapy (Clinical Advances and Basic Research)
Vol. 31, No. 1, Year 2012 (Cover Date: February 2012)
Journal Editor: Gratacós E. (Barcelona)
ISSN: 1015-3837 (Print), eISSN: 1421-9964 (Online)
For additional information: http://www.karger.com/FDT
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