Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot Password? Reset your password

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login (Shibboleth)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Table of Contents
Vol. 58, No. 3, 2012
Issue release date: April 2012
Section title: Behavioural Science Section / Original Paper
Free Access
Gerontology 2012;58:249–257

Multidimensional Predictors of Fatigue among Octogenarians and Centenarians

Cho J.a · Martin P.b · Margrett J.b · MacDonald M.c · Johnson M.A.d · Poon L.W.d · for the Georgia Centenarian Study
aScott & White Health Care, Texas A&M Health Science Center, School of Rural Public Health, College Station, Tex., bGerontology Program, College of Human Sciences, Iowa State University, Ames, Iowa, cCollege of Human Ecology, Kansas State University, Manhattan, Kans., and dCollege of Public Health, University of Georgia, Athens, Ga., USA
email Corresponding Author

Jinmyoung Cho, PhD

Scott & White Health Care, Texas A&M Health Science Center

School of Rural Public Health

College Station, TX 77843-1266 (USA)

Tel. +1 979 458 3507, E-Mail jinmyoung.cho@srph.tamhsc.edu


  1. Poluri A, Mores J, Cook DB, Findley TW, Cristian A: Fatigue in the elderly population. Phys Med Rehabil Clin N Am 2005;16:91–108.
    External Resources
  2. Gialamas A, Beilby JJ, Pratt NL, Henning R, Marley JE, Roddick JF: Investigating tiredness in Australian general practice. Do pathology tests help in diagnosis? Aust Fam Physician 2003;32:663–666.
  3. Murtagh J: Fatigue – a general diagnostic approach. Aust Fam Physician 2003;32:873–876.
  4. Ferrell BR, Grand M, Funk B, Ly J: ‘Bone tired’: the experience of fatigue and its impact on quality of life. Oncol Nurs Forum 1996;23:1539–1547.
  5. Blesch KS, Paice JA, Wichkham R, Harte N, Schnoor DK, Purl S, Rehwalt M, Kopp PL, Mason S, Coveny SB, McHale M, Cahill M: Correlates of fatigue in people with breast or lung cancer. Oncol Nurs Forum 1991;18:81–87.
  6. Cimprich B: Attentional fatigue following breast surgery. Res Nurs Health 1992;15:199–207.
  7. Grant M, Ferrell BR, Schmidt GM, Fonbuena P, Niland JC, Forman SF: Measurement of quality of life in bone marrow transplant survivors. Qual Life Res 1992;1:375–384.
  8. Nail L, Jones L, Greene D, Schipper D, Jensen R: Use and perceived efficacy of self-care activities in patients receiving chemotherapy. Oncol Nurs Forum 1991;18:883–887.
  9. Rhode VA, Watson PM, Hanson BM: Patients descriptions of the influence of tiredness and weakness on self-care abilities. Cancer Nurs 1988;11:186–194.
    External Resources
  10. Rhoten D: Fatigue and postsurgical patient; in Norris C (ed): Concept Clarification in Nursing. Rockville, Aspen, 1982, pp 277–300.
  11. Walke LM, Byers AL, Tinetti ME, Dubin JA, McCorkle R, Fried TR: Range and severity of symptoms over time among alder adults with COPD and HF. Arch Intern Med 2007;167:2503–2508.
  12. Alexander NB, Raffet GE, Horne FM, Eldadah BA, Ferrucci L, Nayfield S, Studenski S: Bedside-to-bench conference: research agenda for idiopathic fatigue and aging. J Am Geriatr Soc 2010;58:967–975.
    External Resources
  13. Wilson MM, Morley JE: Invited review: Aging and energy balance. J Appl Physiol 2003;95:1728–1736.
  14. Martin P, Long MV, Poon LW: Age changes and differences in personality traits and states of the old and very old. J Gerontol B Psychol Sci Soc Sci 2002;57B:P144–P152.
    External Resources
  15. Gill TM, Desai MM, Gahbauer EA, Holford TR, Williams CS: Restricted activity among community-living older persons: incidence, precipitants, and health care utilization. Ann Intern Med 2001;135:313–321.
  16. Dean G, Ferrell BR: The meaning of cancer pain. Semin Oncol Nurs 1995;11:17–21.
    External Resources
  17. Avlund K, Damsgaard MT, Sakari-Rantala R, Laukkanen P, Schroll M: Tiredness in daily activities among non-disabled old people as determinant of onset of disability. J Clin Epidemiol 2002;55:965–973.
  18. Avlund K, Pedersen AN, Schroll M: Functional decline from age 80 to 85: influence of preceding changes in tiredness in daily activities. Psychosom Med 2003;65:771–777.
    External Resources
  19. Avlund K, Sakari-Rantala R, Rantanen T, Pedersen AN, Frandin K, Schroll M: Tiredness and onset of walking limitations in older adults. J Am Geriatr Soc 2004;52:1963–1965.
  20. National Institute on Aging (NIA): Unexplained fatigue in the elderly: an exploratory workshop sponsored by the National Institute on Aging. Unpublished workshop summary, 2007.
  21. Zautra AJ, Fasman R, Parish BP, Davis MC: Daily fatigue in women with osteoarthritis, rheumatoid arthritis, and fibromyalgia. Pain 2007;128:128–135.
    External Resources
  22. Benyamini Y, Ilder EL, Leventhal H, Leventhal EA: Positive affect and function as influences on self-assessment of health. J Gerontol B Psychol Sci Soc Sci 2000;55:P107–P116.
  23. Nakao M, Fricchione G, Zuttermeister PC, Myers P, Barsky AJ, Benson H: Effects of gender and marital status on somatic symptoms of patients attending a mind/body medicine clinic. Behav Med 2001;26:159–168.
  24. Mansuso CA, Rincon M, Sayles W, Paget SA: Psychosocial variables and fatigue: a longitudinal study comparing individuals with rheumatoid arthritis and healthy controls. J Rheumatol 2006;33:1496–1502.
    External Resources
  25. Stewart D, Abbey S, Meana M, Boydell KM: What makes women tired: a community sample. J Womens Health 1988;7:69–76.
  26. Aaronson LS, Pallikkathayil L, Crighton F: Qualitative investigation of fatigue among healthy working women. West J Nurs Res 2003;25:419–433.
  27. Dzurec LC: Relationship as an inherent component in healthy women’s fatigue. West J Nurs Res 2002;24:441–453.
  28. Lenz ER, Pugh LC, Miligan RA, Gift AG, Suppe F: The middle-range theory of unpleasant symptoms: an update. ANS Adv Nurs Sci 1997;19:14–27.
  29. Rhodes VA, Watson PM: Symptom distress – the concept: past and present. Semin Oncol Nurs 1987;3:242–247.
  30. Chen LH, Li CY, Shieh SM, Y WH, Chiou AF: Predictors of fatigue in patients with heart failure. J Clin Nurs 2010;19:1588–1596.
    External Resources
  31. Francoeur RB: The relationship cancer symptom clusters to depressive affect in the initial phase of palliative radiation. J Pain Symptom Manage 2005;29:130–155.
    External Resources
  32. Sarna L, Evangelista D, Tashkin G, Padilla CH, Brecht ML, et al: Impact of respiratory symptoms and pulmonary function on quality of life of long-term survivor of non-small cell lung cancer. Chest 2004;125:439–445.
  33. Wilmonth MC, Colemena EA, Smith SC, Davis C: Fatigue, weight gain and altered sexuality in patients with breast cancer: exploration of a symptom cluster. Oncol Nurs Forum 2004;31:1069–1075.
    External Resources
  34. Lenz ER, Pugh LC: The theory of unpleasant symptoms; in MJ Smith, P Liehr (eds): Middle Range Theory for Nursing. New York, Springer, 2007, pp 159–182.
  35. Hunter SK, Critchlow A, Enoka RM: Influence of aging on sex differences in muscle fatigability. J Appl Physiol 2004;97:1723–1732.
    External Resources
  36. Melzer I, Benjuya N, Kaplanski J: Age related changes in muscle strength and fatigue. Isokinet Exerc Sci 2000;8:73–83.
  37. Hunter SK, Enoka RM: Sex differences in the fatigability of arm muscles depends on absolute force during isometric contractions. J Appl Physiol 2001;91:2686–2694.
  38. Kent-Braun JA, Ng AV, Doyle JW, Towse TF: Human skeletal muscle responses vary with age and gender during fatigue due to incremental isometric exercise. J Appl Physiol 2002;93:1813–1823.
  39. Miller AEJ, Macdougall JD, Tarnopolsky MA, Sale DG: Gender differences in strength and muscle-fiber characteristics. Eur J Appl Physiol O 1993;66:254–262.
  40. Jones AL, Dwyer LL, Bercovitz AR, Strahan GW: The National Nursing Home Survey: 2004 overview. Vital Health Stat 2009;167:1–155.
  41. Shah SM, Carey IM, Harris T, DeWilde S, Hubbard R, Lewis S, Cook DG: Identifying the clinical characteristics of older people living in care homes using a novel approach in a primary care database. Age Ageing 2010;39:617–623.
    External Resources
  42. Tammemagi CM, Neslund-Dudas C, Simoff M, Kvale P: Lung carcinoma symptoms – an independent predictor of survival and an important mediator of African-American disparity in survival. Cancer 2004;101:1655–1663.
    External Resources
  43. Poon LW, Jazwinski SM, Green RC, Woodard JL, Martin P, Rodgers WL, Johnson MA, Hausman D, Arnold J, Davey A, Batzer MA, Markesbery WR., Gearing M, Siegler IC, Reynolds S, Dai J: Methodological considerations in studying centenarians: lessons learned from the Georgia Centenarian Studies; in Poon LW, Perls TT (eds): Annual Review of Gerontology and Geriatrics. New York, Springer, 2007, pp 231–264.
  44. Folstein MF, Folstein SE, McHugh PR: ‘Minimental state’. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
  45. Smets EM, Garssen B, Bonke B, De Haes JC: The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue. J Psychosom Res 1995;39:315–325.
  46. Bensing JM, Hulsman RL, Schreurs KMG: Gender differences in fatigue: biopsychosocial factors relating to fatigue in men and women. Medical Care 1999:37:1078–1083.
  47. Fillenbaum GG: Multidimensional Functional Assessment of Older Adults: The Duke Older Americans Resources and Services Procedures. Hillsdale, Erlbaum, 1988.
  48. Bradburn N: The Structure of Psychological Well-Being. Chicago, Aldine, 1969.
  49. Muthén LK, Muthén BO: Mplus User’s Guide, ed 5. Los Angeles, Muthén & Muthén, 1998.
  50. Adams KB: Depressive symptoms, depletion, or developmental change? Withdrawal, apathy, and lack of vigor in the Geriatric Depression Scale. Gerontologist 2001;41:768–777.
  51. Kwag KH, Martin P, Russell D, Franke W, Kohut M: The impact of perceived stress, social support, and home-based physical activity on mental health among older adults. Int J Aging Hum Dev 2011;72:137–154.
    External Resources
  52. Cho J, Martin P, MacDonald M, Margrett J, Poon LW: The relationship between health and psychological well-being among oldest-old adults. J Aging Res DOI: 10.4061/2011/605041.
    External Resources