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Vol. 21, No. 1-2, 2011
Issue release date: January 2012
Section title: Paper
Free Access
J Mol Microbiol Biotechnol 2011;21:71–81
(DOI:10.1159/000332752)

Specific and Nonspecific Host Adaptation during Arboviral Experimental Evolution

Novella I.S.a · Presloid J.B.a · Smith S.D.a · Wilke C.O.b
aDepartment of Medical Microbiology and Immunology, College of Medicine, University of Toledo Health Science Campus, Toledo, Ohio, and bSection of Integrative Biology, Center for Computational Biology and Bioinformatics, and Institute for Cell and Molecular Biology, University of Texas at Austin, Austin, Tex., USA
email Corresponding Author

Abstract

During the past decade or so, there has been a substantial body of work to dissect arboviral evolution and to develop models of adaptation during host switching. Regardless of what species serve as host or vectors, and of the geographic distribution and the mechanisms of replication, arboviruses tend to have slow evolutionary rates in nature. The hypothesis that this is the result of replication in the disparate environments provided by host and vector did not receive solid experimental support in any of the many viral species tested. Instead, it seems that from the virus’s point of view, either the two environments are sufficiently similar or one of the environments so dominates viral evolution that there is tolerance for suboptimal adaptation to the other environment. Replication in alternating environments has an unexpected cost in that there is decreased genetic variance that translates into a compromised adaptability for bypassed environments. Arboviruses under strong and continuous positive selection may have unusual patterns of genomic changes, with few or no mutations accumulated in the consensus sequence or with dN/dS values typically consistent with random drift in DNA-based organisms.

© 2012 S. Karger AG, Basel


  

Key Words

  • Arboviruses
  • Host switching
  • Adaptation

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Author Contacts

Isabel S. Novella
Department of Microbiology and Immunology
University of Toledo Health Science Campus, Mail stop 1021
Toledo, OH 43614 (USA)
Tel. +1 419 383 6442, E-Mail isabel.novella@utoledo.edu

  

Article Information

Published online: January 13, 2012
Number of Print Pages : 11
Number of Figures : 4, Number of Tables : 1, Number of References : 99

  

Publication Details

Journal of Molecular Microbiology and Biotechnology

Vol. 21, No. 1-2, Year 2011 (Cover Date: January 2012)

Journal Editor: Saier Jr. M.H. (La Jolla, Calif.)
ISSN: 1464-1801 (Print), eISSN: 1660-2412 (Online)

For additional information: http://www.karger.com/MMB


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References

  1. Alto BW, Turner PE: Consequences of host adaptation for performance of vesicular stomatitis virus in novel thermal environments. Evol Ecol 2010;24:299–315.

    External Resources

  2. Anishchenko M, Bowen RA, Paessler S, Austgen L, Greene IP, Weaver SC: Venezuelan encephalitis emergence mediated by a phylogenetically predicted viral mutation. Proc Natl Acad Sci USA 2006;103:4994–4999.
  3. Baranowski E, Ruiz-Jarabo CM, Domingo E: Evolution of cell recognition by viruses. Science 2001;292:1102–1105.
  4. Benmayor R, Hodgson DJ, Perron GG, Buckling A: Host mixing and disease emergence. Curr Biol 2009;19:764–767.
  5. Betancourt AJ: Genomewide patterns of substitution in adaptively evolving populations of the RNA bacteriophage Ms2. Genetics 2009;181:1535–1544.
  6. Bollback JP, Huelsenbeck JP: Clonal interference is alleviated by high mutation rates in large populations. Mol Biol Evol 2007;24:1397–1406.
  7. Brockwell-Staats C, Webster RG, Webby RJ: Diversity of influenza viruses in swine and the emergence of a novel human pandemic influenza a (H1N1). Influenza Other Respi Viruses 2009;3:207–213.
  8. Burch CL, Chao L: Evolvability of an RNA virus is determined by its mutational neighbourhood. Nature 2000;406:625–628.
  9. Burke DS, Monath TP: Flaviviruses; in Knipe DM, Howley PM (eds): Fields Virology, ed 4. Philadelphia, Lippincott Williams & Wilkins, 2001, vol 1, pp 1043–1126.
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  11. Chen WJ, Wu HR, Chiou SS: E/NS1 modifications of dengue 2 virus after serial passages in mammalian and/or mosquito cells. Intervirology 2003;46:289–295.
  12. Ciota AT, Jia Y, Payne AF, Jerzak G, Davis LJ, Young DS, Ehrbar D, Kramer LD: Experimental passage of St. Louis encephalitis virus in vivo in mosquitoes and chickens reveals evolutionarily significant virus characteristics. PLoS One 2009;4:e7876.
  13. Ciota AT, Koch EM, Willsey GG, Davis LJ, Jerzak GV, Ehrbar DJ, Wilke CO, Kramer LD: Temporal and spatial alterations in mutant swarm size of St. Louis encephalitis virus in mosquito hosts. Infect Genet Evol 2011;11:460–468.
  14. Ciota AT, Lovelace AO, Jia Y, Davis LJ, Young DS, Kramer LD: Characterization of mosquito-adapted West Nile virus. J Gen Virol 2008;89:1633–1642.
  15. Ciota AT, Lovelace AO, Jones SA, Payne A, Kramer LD: Adaptation of two flaviviruses results in differences in genetic heterogeneity and virus adaptability. J Gen Virol 2007a;88:2398–2406.
  16. Ciota AT, Lovelace AO, Ngo KA, Le AN, Maffei JG, Franke MA, Payne AF, Jones SA, Kauffman EB, Kramer LD: Cell-specific adaptation of two flaviviruses following serial passage in mosquito cell culture. Virology 2007b;357:165–174.
  17. Ciota AT, Ngo KA, Lovelace AO, Payne AF, Zhou Y, Shi PY, Kramer LD: Role of the mutant spectrum in adaptation and replication of West Nile virus. J Gen Virol 2007c;88:865–874.
  18. Coffey LL, Vasilakis N, Brault AC, Powers AM, Tripet F, Weaver SC: Arbovirus evolution in vivo is constrained by host alternation. Proc Natl Acad Sci USA 2008;105:6970–6975.
  19. Coffey LL, Vignuzzi M: Host alternation of Chikungunya virus increases fitness while restricting population diversity and adaptability to novel selective pressures. J Virol 2011;85:1025–1035.
  20. Cooper LA, Scott TW: Differential evolution of eastern equine encephalitis virus populations in response to host cell type. Genetics 2001;157:1403–1412.
  21. de la Torre JC, Holland JJ: RNA virus quasispecies populations can suppress vastly superior mutant progeny. J Virol 1990;64:6278–6281.
  22. de Mattos CA, de Mattos CC, Rupprecht CE: Rhabdoviruses; in Knipe DM, Howley PM (eds): Fields Virology, ed 4. Philadelphia, Lippincott Williams & Wilkins, 2001, vol 1, pp 1245–1278.
  23. Denison MR, Graham RL, Donaldson EF, Eckerle LD, Baric RS: Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. RNA Biol 2011;8:270–279.
  24. Devictor V, Clavel J, Julliard R, Lavergne S, Mouillot D, Thuiller W, Venail P, Villéger S, Moquet N: Defining and measuring ecological specialization. J Appl Ecol 2010;47:15–25.

    External Resources

  25. Domingo E, Holland JJ: RNA virus mutations and fitness for survival. Annu Rev Microbiol 1997;51:151–178.
  26. Drake JW, Holland JJ: Mutation rates among RNA viruses. Proc Natl Acad Sci USA 1999;96:13910–13913.
  27. Dutta RN, Rouzine IM, Smith SD, Wilke CO, Novella IS: Rapid adaptive amplification of preexisting variation in an RNA virus. J Virol 2008;82:4354–4362.
  28. Eigen M: On the nature of virus quasispecies. Trends Microbiol 1996;4:216–218.
  29. Elena SF, Lenski RE: Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation. Nat Rev Genet 2003;4:457–469.
  30. Elena SF, Sanjuan R: Adaptive value of high mutation rates of RNA viruses: separating causes from consequences. J Virol 2005;79:11555–11558.
  31. Ferris MT, Joyce P, Burch CL: High frequency of mutations that expand the host range of an RNA virus. Genetics 2007;176:1013–1022.
  32. Fitzpatrick KA, Deardorff ER, Pesko K, Brackney DE, Zhang B, Bedrick E, Shi PY, Ebel GD: Population variation of West Nile virus confers a host-specific fitness benefit in mosquitoes. Virology 2010;404:89–95.
  33. Gould EA, de Lamballerie X, Zanotto PM, Holmes EC: Origins, evolution, and vector/host coadaptations within the genus flavivirus. Adv Virus Res 2003;59:277–314.
  34. Grande-Perez A, Gomez-Mariano G, Lowenstein PR, Domingo E: Mutagenesis-induced, large fitness variations with an invariant arenavirus consensus genomic nucleotide sequence. J Virol 2005;79:10451–10459.
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