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Table of Contents
Vol. 73, No. 1, 2012
Issue release date: March 2012
Section title: Original Paper
Free Access
Hum Hered 2012;73:1–13

A Generalized Sequential Bonferroni Procedure Using Smoothed Weights for Genome-Wide Association Studies Incorporating Information on Hardy-Weinberg Disequilibrium among Cases

Gao G.a · Kang G.b · Wang J.a · Chen W.a · Qin H.c · Jiang B.d · Li Q.e · Sun C.a · Liu N.d · Archer K.J.a · Allison D.B.d
aDepartment of Biostatistics, Virginia Commonwealth University, Richmond, Va., bDepartment of Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, Pa., cDepartment of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, Ohio, and dDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, Ala., USA; eAcademy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, PR China
email Corresponding Author

Guimin Gao

Department of Biostatistics, Virginia Commonwealth University

PO Box 980032

Richmond, VA 23298-0032 (USA)

Tel. +1 804 827 2775, E-Mail ggao3@vcu.edu


  1. Cochran WG: Some methods for strengthening the common χ2 tests. Biometrics 1954;10:417–451.
    External Resources
  2. Armitage P: Tests for linear trends in proportions and frequencies. Biometrics 1955;11:375–386.
    External Resources
  3. Sasieni PD: From genotypes to genes: doubling the sample size. Biometrics 1997;53:1253–1261.
  4. Zheng G, Ng HKT: Genetic model selection in two-phase analysis for case-control association studies. Biostatistics 2008;9:391–399.
  5. Nielsen DM, Ehm MG, Weir BS: Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus. Am J Hum Genet 1999;63:1531–1540.
  6. Song K, Elston RC: A powerful method of combining measures of association and Hardy-Weinberg disequilibrium for fine-mapping in case-control studies. Stat Med 2006;25:105–126.
  7. Fisher RA: Statistical Methods for Research Workers. Oliver and Boyd, London, 1932.
  8. Hoh J, Wille A, Ott J: Trimming, weighting, and grouping SNPs in human case-control association studies. Genome Res 2001;11:2115–2119.
  9. Freidlin B, Zheng G, Li Z, Gastwirth JL: Trend tests for case-control studies of genetic markers: power, sample size and robustness. Hum Hered 2002;53:146–152 (erratum in Hum Hered 2009;68:220).
  10. Li Q, Zheng G, Li Z, Yu K: Efficient approximation of P-value of the maximum of correlated tests, with applications to genome-wide association studies. Ann Hum Genet 2008;72:397–406.
  11. Zang Y, Fung WK, Zheng G: Simple algorithms to calculate asymptotic null distributions for robust tests in case-control genetic association studies in R. J Stat Softw 2010;33:issue 8.
  12. Joo J, Kwak M, Zheng G: Improving power for testing genetic association in case-control studies by reducing alternative space. Biometrics 2009;66:266–276.
  13. Joo J, Kwak M, Ahn K, Zheng G: A robust genome-wide scan statistic of the Wellcome Trust Case-Control Consortium. Biometrics 2009;65:1115–1122.
  14. Holm S: A simple sequentially rejective multiple test procedure. Scand J Statist 1979;6:65–70.
    External Resources
  15. The Wellcome Trust Case Control Consortium (WTCCC): Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661–683.
  16. Weir BS: Genetic Data Analysis II: Methods for Discrete Population Genetic Data. Sinauer Associates, Inc., Sunderland, Mass., 1996.
  17. Zang Y, Fung WK, Zheng G: Tail strength to combine two p values: their correlation cannot be ignored. Am J Hum Genet 2009;84:291–295.
  18. Wigginton JE, Cutler DJ, Abecasis GR: A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 2005;76:887–893.
  19. Yates F: Contingency tables involving small numbers and the χ2 test. J R Stat Soc (suppl) 1934;1:217–235.
  20. Kang G, Ye K, Liu N, Allison DB, Gao G: Weighted multiple hypothesis testing procedures. Stat Appl Genet Mol Biol 2009;8:Article 23.
  21. Roeder K, Wasserman L: Genome-wide significance levels and weighted hypothesis testing. Stat Sci 2009;24:398–413.
  22. Roeder K, Devlin B, Wasserman L: Improving power in genome-wide association studies: weights tip the scale. Genet Epidemiol 2007;31:741–747.
  23. Rohlfs RV, Weir BS: Distributions of Hardy-Weinberg equilibrium test statistics. Genetics 2008;180:1609–1616.
  24. Schaid DJ, Sommer SS: Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 1993;53:1114–1126.
  25. Terwilliger JD, Ott J: Handbook of Human Genetic Linkage. Johns Hopkins University Press, Baltimore, 1994.
  26. Wu MC, Kraft P, Epstein MP, Taylor DM, Chanock SJ, Hunter DJ, Lin X: Powerful SNP-set analysis for case-control genome-wide association studies. Am J Hum Genet 2010;86:929–942.
  27. Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA, Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 2006;38:904–909.
  28. Serfling RJ: Approximation Theorems of Mathematical Statistics. John Wiley & Sons, New York, 1980.