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Vol. 81, Suppl. 1, 2011
Issue release date: December 2011
Section title: Paper
Oncology 2011;81(suppl 1):24–29
(DOI:10.1159/000333256)

Signaling Pathways Governing Tumor Angiogenesis

Sakurai T. · Kudo M.
Department of Gastroenterology and Hepatology, Kinki University, Osakasayama, Japan

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/22/2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Angiogenesis is regulated by the highly coordinated function of various proteins with pro- and antiangiogenic functions. Proangiogenic factors include vascular endothelial growth factor (VEGF), fibroblast growth factor, platelet-derived growth factor, insulin-like growth factor, transforming growth factor, angiopoietins, and several chemokines; antiangiogenic factors include thrombospondin-1, angiostatin, and endostatin. Matrix metalloproteinases display a dual role in vascular development. Notch signaling affects remodeling of the primary vascular network of uniformly sized vessels into functionally and morphologically distinct arteries, veins, and capillaries. Tumors, described as ‘wounds that never heal’, lose the appropriate balance among these factors. Although VEGF-targeted therapies are showing promise, new angiogenesis targets are needed to make additional gains. Here, we highlight recent advances in our understanding of the regulation of tumor angiogenesis and discuss the potential of molecular targeting as a new therapeutic approach.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 12/22/2011

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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