Free Access
Neuroepidemiology 2012;38:1–17
(DOI:10.1159/000334607)

Prevalence of Apolipoprotein E4 Genotype and Homozygotes (APOE e4/4) among Patients Diagnosed with Alzheimer’s Disease: A Systematic Review and Meta-Analysis

Ward A.a · Crean S.a · Mercaldi C.J.b · Collins J.M.a · Boyd D.a · Cook M.N.c · Arrighi H.M.d
aCenter for Epidemiology and Database Analytics, United BioSource Corporation, Lexington, Mass., bCenter for Epidemiology and Database Analytics, United BioSource Corporation, Bethesda, Md., cPfizer Inc., Collegeville, Pa., and dJANSSEN Alzheimer Immunotherapy Research and Development, LLC, South San Francisco, Calif., USA
email Corresponding Author


 goto top of outline Key Words

  • Alzheimer’s disease
  • Apolipoprotein E
  • Meta-analysis
  • Prevalence
  • Epidemiology

 goto top of outline Abstract

Background: Population allele frequencies of apolipoprotein E (APOE) vary by geographic region. The purpose of this study is to summarize and evaluate published estimates for the prevalence of APOE e4 carrier status among the population diagnosed with Alzheimer’s disease (AD) by geographic region and country. Methods: A systematic review of English-language publications from January 1, 1985, through May 31, 2010, was conducted. Studies reporting APOE e4 status for patients diagnosed with AD were included in the analysis; trials and autopsies were excluded. APOE e4 data were pooled, and prevalence and 95% confidence intervals (CIs) were calculated. Results: Pooled estimates for APOE e4 carrier prevalence data were derived from 142 independent samples: 48.7% (95% CI: 46.5–51.0), and from 73 samples for e4/4 (homozygotes): 9.6% (95% CI: 8.4–10.8). The highest estimates were in Northern Europe: 61.3% (95% CI: 55.9–66.7), e4/4 prevalence: 14.1% (95% CI: 12.2–16.0). The lowest estimates were in Asia and Southern Europe. Substantial heterogeneity of these prevalence estimates was observed. Conclusions: APOE e4 genotype prevalence varies among AD patients by region and within each country. Further exploration is warranted to better understand the substantial heterogeneity of these prevalence estimates.

Copyright © 2011 S. Karger AG, Basel


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 goto top of outline Author Contacts

Alex Ward, PhD, MRPharmS
United BioSource Corporation
430 Bedford St., Suite 300
Lexington, MA 02420 (USA)
Tel. +1 781 960 0227, E-Mail alex.ward@unitedbiosource.com


 goto top of outline Article Information

Received: November 23, 2010
Accepted: October 19, 2011
Published online: December 17, 2011
Number of Print Pages : 17
Number of Figures : 2, Number of Tables : 7, Number of References : 154


 goto top of outline Publication Details

Neuroepidemiology

Vol. 38, No. 1, Year 2012 (Cover Date: January 2012)

Journal Editor: Feigin V.L. (Auckland)
ISSN: 0251-5350 (Print), eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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