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Vol. 159, No. 1, 2012
Issue release date: August 2012

Sensitization to Common Ragweed in Southern Bavaria: Clinical and Geographical Risk Factors in Atopic Patients

Ruëff F. · Przybilla B. · Walker A. · Gmeiner J. · Kramer M. · Sabanés-Bové D. · Küchenhoff H. · Herzinger T.
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Abstract

Background: Sensitization to common ragweed (Ambrosia artemisiifolia) is associated with a variety of risk factors, which are incompletely defined. Our aim was to evaluate the association of a variety of clinical, geographical and demographical variables with ragweed sensitization and also to determine its frequency in southern Bavaria. Methods: In this cross-sectional multicentre study, we enrolled 977 patients with a documented or suspected atopic disease or food allergy. Data were collected on aeroallergen sensitization, age, sex, type and history of allergic disease, place of residence and potential local ragweed exposure. For this last variable, county ragweed cover was taken as a surrogate variable. Relative rates were calculated with multiple additive logistic regression models. Randomly selected patients with ragweed sensitization had a conjunctival provocation test. Results: According to skin prick tests, 190 patients (19.5%) were sensitized to ragweed. The frequency of this finding increased significantly with a rising number of additional sensitizations. Other less important predictors for a ragweed sensitization were male gender, mugwort sensitization, food allergy and a maximum of complaints in September or October. County of residence, extent of local ragweed cover or type of residential area were without relevance. Of 48 sensitized patients, 26 (54.2%) had a positive conjunctival provocation test. Discussion: Patients with multiple sensitizations may be more readily sensitized to a new aeroallergen. Local geographic or environmental conditions are presumably of minor importance for becoming sensitized to ragweed. The frequency of ragweed allergy among sensitized patients might be high.



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References

  1. Björkstén B, Clayton T, Ellwood P, Stewart A, Strachan D, ISAAC Phase III Study Group: Worldwide time trends for symptoms of rhinitis and conjunctivitis: phase III of the International Study of Asthma and Allergies in Childhood. Pediatr Allergy Immunol 2008;19:110–124.
  2. Zizka LH, Caulfield FA: The potential influence of rising atmospheric carbon dioxide (CO2) on pollen production of common ragweed as a test case. World Resour Rev 2000;12:449–457.
  3. Wallace DV, Dykewicz MS, Bernstein DI, Blessing-Moore J, Cox L, Khan DA, Lang DM, Nicklas RA, Oppenheimer J, Portnoy JM, Randolph CC, Schuller D, Spector SL, Tilles SA, Joint Task Force on Practice, American Academy of Allergy (Asthma & Immunology), American College of Allergy (Asthma and Immunology), Joint Council of Allergy (Asthma and Immunology): The diagnosis and management of rhinitis: an updated practice parameter. J Allergy Clin Immunol 2008;122(2 suppl):S1–S84.

    External Resources

  4. D’Amato G, Cecchi L, Bonini S, Nunes C, Annesi-Maesano I, Behrendt H, Liccardi G, Popov T, van Cauwenberge P: Allergenic pollen and pollen allergy in Europe. Allergy 2007;62:976–990.
  5. Basset IJ, Crompton CW: The biology of Canadian weeds. II. Ambrosia artemisiifolia L. and A. psilostachya DC. Can J Plant Sci 1975;55:463–476.

    External Resources

  6. Corsico R, Falagiani P, Ariano R, Berra D, Biale C, Bonifazi F, Campi P, Feliziani V, Frenguelli, G, Galimberti M, Gallesio MT, Liccardi, G, Loreti A, Marcer G, Marcucci F, Meriggi A, Minelli M, Nardelli R, Nardi G, Negrini CA, Papa G, Piu G, Pozzan M, D’Ambrosio FP, Riva G: An epidemiological survey on the allergological importance of some emerging pollens in Italy. J Investig Allergol Clin Immunol 2000;10:155–161.
  7. Bousquet PJ, Chinn S, Janson C, Kogevinas M, Burney P, Jarvis D: Geographical variation in the prevalence of positive skin tests to environmental aeroallergens in the European Community Respiratory Health Survey. I. Allergy 2007;62:301–309.
  8. Alberternst B, Nawrath S: Spreading and distribution of common ragweed (Ambrosia artemisiifolia) in Germany. Proceedings of the 4th European Symposium on Aerobiology, Turku, 2008.
  9. Jäger S: Ragweed (Ambrosia) sensitization rates correlate with the amount of inhaled airborne pollen. A 14-year study in Vienna, Austria. Aerobiologia 2000;16:149–153.

    External Resources

  10. Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, Sicherer S, Golden DB, Khan DA, Nicklas RA, Portnoy JM, Blessing-Moore J, Cox L, Lang DM, Oppenheimer J, Randolph CC, Schuller DE, Tilles SA, Wallace DV, Levetin E, Weber R, American Academy of Allergy (Asthma and Immunology), American College of Allergy (Asthma and Immunology): Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008;100(suppl 3):S1–S148.

    External Resources

  11. Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M, Cooper SF, Fenton MJ, Arshad SH, Bahna SL, Beck LA, Byrd-Bredbenner C, Camargo CA Jr, Eichenfield L, Furuta GT, Hanifin JM, Jones C, Kraft M, Levy BD, Lieberman P, Luccioli S, McCall KM, Schneider LC, Simon RA, Simons FE, Teach SJ, Yawn BP, Schwaninger JM: Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010;126(6 suppl):S1–S58.
  12. Alberternst B, Nawrath S, Klingenstein F: Biologie. Verbreitung und Einschleppung von Ambrosia artemisiifolia in Deutschland und Bewertung aus Naturschutzsicht. Nachrichtenbl Deut Pflanzenschutzd 2006;58:279–285.
  13. Heinzerling LM, Burbach GJ, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini, S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Burney P, Canonica GW, Darsow U, Demoly P, Durham S, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Haahtela T, Kowalski ML, Magyar P, Muraközi G, Orosz M, Papadopoulos NG, Röhnelt C, Stingl G, Todo-Bom A, von Mutius E, Wiesner A, Wöhrl S, Zuberbier T: GA2LEN skin test study I: GA2LEN harmonization of skin prick testing: novel sensitization patterns for inhalant allergens in Europe. Allergy 2009;64:1498–1506.
  14. Möller C, Bjorksten B, Nilsson G, Dreborg S: The precision of the conjunctival provocation test. Allergy 1984;39:37–41.
  15. Gelman A, Carlin JB, Stern HS, Rubin DB: Bayesian Data Analysis. Boca Raton, Chapman & Hall/CRC, 2004.
  16. Belitz C, Brezger A, Kneib T, Lang S: BayesX – software for Bayesian inference in structured additive regression models. Version 2.0. http://www.stat.uni-muenchen.de/ ∼bayesx. 2002.
  17. Spiegelhalter DJ, Best NG, Carlin BR, van der Linde A: Bayesian measures of model complexity and fit. J R Stat Soc Series B. 2002;64:583–616.

    External Resources

  18. Kim KW, Kim EA, Kwon BC, Kim ES, Song TW, Sohn MH: Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma. J Korean Med Sci 2006;21:1012–1016.
  19. Schäfer T, Heinrich J, Wjst M, Adam H, Ring J, Wichmann H-E: Association between severity of atopic eczema and degree of sensitization to aeroallergens in schoolchildren. J Allergy Clin Immunol 1999;104:1280–1284.
  20. Pallasaho P, Rönmark E, Haahtela T, Sovijärvi AR, Lundbäck B: Degree and clinical relevance of sensitization to common allergens among adults: a population study in Helsinki, Finland. Clin Exp Allergy 2006;36:503–509.
  21. Burbach GJ, Heinzerling LM, Edenharter G, Bachert C, Bindslev-Jensen C, Bonini, S, Bousquet J, Bousquet-Rouanet L, Bousquet PJ, Bresciani M, Bruno A, Canonica GW, Darsow U, Demoly P, Durham S, Fokkens WJ, Giavi S, Gjomarkaj M, Gramiccioni C, Haahtela T, Kowalski ML, Magyar P, Muraközi G, Orosz M, Papadopoulos NG, Röhnelt C, Stingl G, Todo-Bom A, von Mutius E, Wiesner A, Wöhrl S, Zuberbier T: GA(2)LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe. Allergy 2009;64:1507–1515.
  22. Kang H, Yu J, Yoo Y, Kim DK, Koh YY: Coincidence of atopy profile in terms of monosensitization and polysensitization in children and their parents. Allergy 2005;60:1029–1033.
  23. Yoo Y, Yu J, Kim DK, Choi SH, Koh YY: Coincidence of atopy and its profile (monosensitization/polysensitization) between sibling pairs. Ann Allergy Asthma Immunol 2005;95:433–437.

    External Resources

  24. Fasce L, Tosca MA, Baroffio M, Olcese R, Ciprandi G: Atopy in wheezing infants always starts with monosensitization. Allergy Asthma Proc 2007;28:449–453.

    External Resources

  25. Silvestri M, Rossi GA, Cozzani S, Pulvirenti G, Fasce L: Age-dependent tendency to become sensitized to other classes of aeroallergens in atopic asthmatic children. Ann Allergy Asthma Immunol 1999;83:335–340.
  26. Schnuch A, Brasch J, Uter W: Polysensitization and increased susceptibility in contact allergy: a review. Allergy 2008;63:156–167.
  27. Friedmann PS: Graded continuity, or all or none – studies of the human immune response. Clin Exp Dermatol 1991;16:79–84.
  28. Dittrich AM, Chen HC, Xu L, Ranney P, Connolly S, Yarovinsky TO, Bottomly HK: A new mechanism for inhalational priming: IL-4 bypasses innate immune signals. J Immunol 2008;181:7307–7315.
  29. Pene J, Rivier A, Lagier B, Becker WM, Michel FB, Bousquet J: Differences in IL-4 release by PBMC are related with heterogeneity of atopy. Immunology 1994;81:58–64.
  30. Sikoparija B, Radisic P, Pejak T, Simic S: Airborne grass and ragweed pollen in the southern Panonnian Valley – consideration of rural and urban environment. Ann Agric Environ Med 2006;13:263–266.

    External Resources

  31. Chan-Yeung M, Anthonisen NR, Becklake MR, Bowie D, Sonia Buist A, Dimich-Ward H, Ernst P, Sears MR, Siersted HC, Sweet L, Van Til L, Manfreda J: Geographical variations in the prevalence of atopic sensitization in six study sites across Canada. Allergy 2010;65:1404–1413.
  32. Kasprzyk I: Non-native Ambrosia pollen in the atmosphere of Rzeszów (SE Poland): evaluation of the effect of weather conditions on daily concentrations and starting dates of the pollen season. Int J Biometeorol 2008;52:341–351.

    External Resources

  33. Kerkhof M, Postma DS, Schouten JP, de Monchy JG: Allergic sensitization to indoor and outdoor allergens and relevance to bronchial hyperresponsiveness in younger and older subjects. Allergy 2003;58:1261–1267.
  34. Asero R: Birch and ragweed pollinosis north of Milan: a model to investigate the effects of exposure to ‘new’ airborne allergens. Allergy 2002;57:1063–1066.
  35. WHO/ICIS/EPN: Phenology and human health: allergic disorders. WHO Meeting report, Rome, 2003, 56 pp. http://www.pollenwarndienst.at/upload/images/original/719.pdf.
  36. Burbach GJ, Heinzerling LM, Röhnelt C, Bergmann KC, Behrendt H, Zuberbier T: Ragweed sensitization in Europe – GA(2)LEN study suggests increasing prevalence. Allergy 2009;64:664–665.
  37. Asero R: Pollen specific immunotherapy is not a risk factor for de novo sensitization to cross-reacting allergens in monosensitized subjects. J Investig Allergol Clin Immunol 2006;16:253–257.
  38. Asero R: Injection immunotherapy with different airborne allergens did not prevent de novo sensitization to ragweed and birch pollen north of Milan. Int Arch Allergy Immunol 2004;133:49–54.
  39. Harmanci K, Razi CH, Toyran M, Kanmaz G, Cengizlier MR: Evaluation of new sensitizations in asthmatic children monosensitized to house dust mite by specific immunotherapy. Asian Pac J Allergy Immunol 2010;28:7–13.

    External Resources

  40. Tella R, Bartra J, San Miguel M, Olona M, Bosque M, Gaig P, Garcia-Ortega P: Effects of specific immunotherapy on the development of new sensitisations in monosensitised patients. Allergol Immunopathol (Madr) 2003;31:221–225.
  41. Laaidi M, Laaidi K, Besancenot JP, Thibaudon M: Ragweed in France: an invasive plant and its allergenic pollen. Ann Allergy Asthma Immunol 2003;91:195–201.
  42. Fumanal B, Chauvel B, Bretagnolle F: Estimation of pollen and seed production of common ragweed in France. Ann Agric Environ Med 2007;14:233–236.

    External Resources



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