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Table of Contents
Vol. 88, No. 2, 2012
Issue release date: March 2012
Section title: Original Paper
Urol Int 2012;88:158–164
(DOI:10.1159/000335299)

CD10 Is Inversely Associated with Nuclear Factor-Kappa B and Predicts Biochemical Recurrence after Radical Prostatectomy

Voutsadakis I.A. · Vlachostergios P.J. · Daliani D.D. · Karasavvidou F. · Kakkas G. · Moutzouris G. · Melekos M.D. · Papandreou C.N.
Departments of aMedical Oncology, bPathology and cUrology, University Hospital of Larissa, University of Thessaly School of Medicine, Larissa, Greece; dMultidisciplinary Center for Oncology, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/7/2011
Accepted: 11/23/2011
Published online: 1/28/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: The cell surface endopeptidase CD10 (neutral endopeptidase) and nuclear factor-ĸB (NF-ĸB) have been independently associated with prostate cancer (PC) progression. We investigated the correlations between these two factors and their prognostic relevance in terms of biochemical (prostate-specific antigen, PSA) relapse after radical prostatectomy (RP) for localized PC. Patients and Methods: The immunohistochemical expression of CD10 and NF-ĸB in samples from 70 patients who underwent RP for localized PC was correlated with the preoperative PSA level, Gleason score, pathological stage and time to PSA failure. Results: CD10 expression was inversely associated with NF-ĸB expression (p < 0.001), stage (p = 0.03) and grade (p = 0.003), whereas NF-ĸB was directly related with stage (p = 0.006) and grade (p = 0.002). The median time to PSA failure was 56 months. CD10 and NF-ĸB were directly (p < 0.001) and inversely (p < 0.001) correlated with biochemical recurrence-free survival, respectively. CD10 expression (p = 0.022) and stage (p = 0.018) were independently associated with time to biochemical recurrence. Conclusion: Low CD10 expression is an adverse prognostic factor for biochemical relapse after RP in localized PC, which is also associated with high NF-ĸB expression. Decreased CD10 expression which would lead to increased neuropeptide signaling and NF-ĸB activity may be present in a subset of early PCs.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/7/2011
Accepted: 11/23/2011
Published online: 1/28/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 4

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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