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Vol. 223, No. 4, 2011
Issue release date: March 2012
Section title: Original Paper
Dermatology 2011;223:370–373
(DOI:10.1159/000335571)

Linear Pitting and Splinter Haemorrhages Are More Commonly Seen in the Nails of Patients with Established Psoriasis in Comparison to Psoriatic Arthritis

Palmou N. · Marzo-Ortega H. · Ash Z. · Goodfield M. · Coates L.C. · Helliwell P.S. · McGonagle D.
aSection of Rheumatology, Villarrobledo Hospital, General Universitary Albacete Hospital, Albacete, Spain; bSection of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust and cDepartment of Dermatology, Leeds Teaching Hospitals NHS Trust, Leeds, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/14/2011 8:19:51 AM
Accepted: 12/3/2011
Published online: 2/2/2012

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Recently the role of several ligament and tendon insertions around the nail matrix and nail plate have been identified as possible contributory factors that explain the higher prevalence of nail involvement in psoriatic arthritis (PsA). The purpose of this study was to determine whether such anatomical factors might also be associated with different patterns of nail involvement in skin psoriasis and PsA. Methods: A total of 173 patients were recruited: 121 PsA cases and 52 psoriasis cases. All patients had a standardised assessment of the nails for lesions including pitting, splinter haemorrhages and onycholysis. Results: The overall modified Nail Psoriasis Severity Index scores did not differ between the two groups (psoriasis mean 8.5, SD 7.1; PsA mean 8.3, SD 9.4). In the nail matrix, linear pitting appeared to be more common in skin psoriasis (OR 0.27, 95% CI 0.18–0.41). There were no significant differences in the distribution of nail plate abnormalities other than splinter haemorrhages which were more commonly seen in psoriasis cases (OR 0.23, 95% CI 0.14–0.39). Conclusion: The pattern of nail disease in psoriasis and PsA differed with respect to the frequency of linear pitting and splinter haemorrhages, with both features occurring more often in psoriasis.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/14/2011 8:19:51 AM
Accepted: 12/3/2011
Published online: 2/2/2012

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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