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Vol. 10, No. 1-4, 2012
Issue release date: April 2012
Neurodegenerative Dis 2012;10:187–190

Prevalence and Profile of Mild Cognitive Impairment in Parkinson’s Disease

Monastero R. · Di Fiore P. · Ventimiglia G.D. · Ventimiglia C.C. · Battaglini I. · Camarda R. · Camarda C.
Laboratory of Epidemiology and Psychology of Aging and Dementia (LEPAD), Department of Experimental Biomedicine and Clinical Neuroscience (BioNeC), University of Palermo, Palermo, Italy

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Background/Aims: The frequency of mild cognitive impairment (MCI) in Parkinson’s disease (PD) ranges from 19 to 40%, and this is probably due to methodological differences between the studies. The aim of this study was to evaluate the frequency and profile of MCI in a large sample of nondemented PD subjects and neurologically healthy subjects (NHS). Methods: A total of 872 subjects (582 controls and 290 PD) were included. The association between MCI and PD was tested, using logistic regression models; odds ratios (OR) with 95% confidence intervals (CI) were calculated. Results: Fifty-three percent of PD subjects and 45% NHS met the criteria for MCI (p = 0.001). The PD subjects showed a higher frequency of nonamnestic MCI (naMCI), compared to NHS (23.8 vs. 14.4%, p ≤ 0.0001). In comparison to NHS, PD was associated with a univariate OR of 1.9 (95% CI = 1.3–2.8) for naMCI, and this association was marginally significant after multiple comparisons (multivariate OR = 1.5, 95% CI = 0.96–2.3, p = 0.077). Conclusion: The association between PD and the impairment of nonmemory domains is probably due to frontal-subcortical involvement, which characterizes the disease.

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