Journal Mobile Options
Table of Contents
Vol. 58, No. 5, 2012
Issue release date: August 2012
Section title: Experimental Section / Viewpoint
Gerontology 2012;58:441–445
(DOI:10.1159/000336149)

Brain Plasticity, Sleep and Aging

Cirelli C.
Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisc., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restriction apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Experimental Section / Viewpoint

Received: 11/11/2011 10:42:30 AM
Accepted: 1/3/2012
Published online: 3/6/2012

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER

Abstract

The link between sleep and aging is a hot topic of research. On the one hand, much attention has been paid to epidemiological studies showing that both short sleep and long sleep in humans are associated with reduced longevity. I will briefly review this literature and discuss recent experiments in the fruit fly Drosophila melanogaster that may contribute to understanding this complicated association. On the other hand, other experiments have focused on age-related sleep changes. Sleep quantity and quality tend to decrease with age, but the underlying mechanisms remain unclear. In young subjects, converging evidence from human and animal studies shows that the need for sleep is strongly modulated by the amount of brain plasticity during prior wake. In short, the more we learn and adapt our brain to an ever-changing environment, the more we need to sleep. If so, poor sleep in the elderly could be caused by a chronic decrease in sleep need due to reduced opportunity to learn and be exposed to novel experiences, rather than, or in addition to, an intrinsic problem in the neural circuits responsible for sleep regulation. This distinction has obvious practical implications. However, very little research has been done on this topic.


Article / Publication Details

First-Page Preview
Abstract of Experimental Section / Viewpoint

Received: 11/11/2011 10:42:30 AM
Accepted: 1/3/2012
Published online: 3/6/2012

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 0

ISSN: 0304-324X (Print)
eISSN: 1423-0003 (Online)

For additional information: http://www.karger.com/GER


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Hammond EC: Some preliminary findings on physical complaints from a prospective study of 1,064,004 men and women. Am J Public Health Nations Health 1964;54:11–23.
  2. Kripke DF, Simons RN, Garfinkel L, Hammond EC: Short and long sleep and sleeping pills. Is increased mortality associated? Arch Gen Psychiatry 1979;36:103–116.
  3. Wingard DL, Berkman LF: Mortality risk associated with sleeping patterns among adults. Sleep 1983;6:102–107.
  4. Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR: Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002;59:131–136.
  5. Pollak CP, Perlick D, Linsner JP, Wenston J, Hsieh F: Sleep problems in the community elderly as predictors of death and nursing home placement. J Community Health 1990;15:123–135.
  6. Kojima M, Wakai K, Kawamura T, Tamakoshi A, Aoki R, Lin Y, Nakayama T, Horibe H, Aoki N, Ohno Y: Sleep patterns and total mortality: a 12-year follow-up study in Japan. J Epidemiol 2000;10:87–93.
  7. Mallon L, Broman JE, Hetta J: Sleep complaints predict coronary artery disease mortality in males: a 12-year follow-up study of a middle-aged Swedish population. J Intern Med 2002;251:207–216.
  8. Dew MA, Hoch CC, Buysse DJ, Monk TH, Begley AE, Houck PR, Hall M, Kupfer DJ, Reynolds CF 3rd: Healthy older adults’ sleep predicts all-cause mortality at 4 to 19 years of follow-up. Psychosom Med 2003;65:63–73.
  9. Tamakoshi A, Ohno Y; JACC Study Group: Self-reported sleep duration as a predictor of all-cause mortality: results from the JACC study, Japan. Sleep 2004;27:51–54.
  10. Hublin C, Partinen M, Koskenvuo M, Kaprio J: Sleep and mortality: a population-based 22-year follow-up study. Sleep 2007;30:1245–1253.

    External Resources

  11. Ferrie JE, Shipley MJ, Cappuccio FP, Brunner E, Miller MA, Kumari M, Marmot MG: A prospective study of change in sleep duration: associations with mortality in the Whitehall II cohort. Sleep 2007;30:1659–1666.

    External Resources

  12. Ikehara S, Iso H, Date C, Kikuchi S, Watanabe Y, Wada Y, Inaba Y, Tamakoshi A: Association of sleep duration with mortality from cardiovascular disease and other causes for Japanese men and women: the JACC study. Sleep 2009;32:295–301.
  13. Youngstedt SD, Kripke DF: Long sleep and mortality: rationale for sleep restriction. Sleep Med Rev 2004;8:159–174.
  14. Foley DJ: An epidemiological perspective on one tale of a two-tailed hypothesis. Sleep Med Rev 2004;8:155–157, discussion 175–156.

    External Resources

  15. Bliwise DL, Young TB: The parable of parabola: what the U-shaped curve can and cannot tell us about sleep. Sleep 2007;30:1614–1615.

    External Resources

  16. Leineweber C, Kecklund G, Janszky I, Akerstedt T, Orth-Gomer K: Poor sleep increases the prospective risk for recurrent events in middle-aged women with coronary disease. The Stockholm Female Coronary Risk Study. J Psychosom Res 2003;54:121–127.
  17. Nilsson PM, Roost M, Engstrom G, Hedblad B, Berglund G: Incidence of diabetes in middle-aged men is related to sleep disturbances. Diabetes Care 2004;27:2464–2469.
  18. Nilsson PM, Nilsson JA, Hedblad B, Berglund G: Sleep disturbance in association with elevated pulse rate for prediction of mortality – consequences of mental strain? J Intern Med 2001;250:521–529.
  19. Ekstedt M, Akerstedt T, Soderstrom M: Microarousals during sleep are associated with increased levels of lipids, cortisol, and blood pressure. Psychosom Med 2004;66:925–931.
  20. Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB: Correlates of long sleep duration. Sleep 2006;29:881–889.
  21. Patel SR: Sleep – an affair of the heart. Sleep 2009;32:289–290.
  22. Spiegel K, Leproult R, Van Cauter E: Impact of sleep debt on metabolic and endocrine function. Lancet 1999;354:1435–1439.
  23. Gonzalez-Ortiz M, Martinez-Abundis E, Balcazar-Munoz BR, Pascoe-Gonzalez S: Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects. Diabetes Nutr Metab 2000;13:80–83.
  24. Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM: Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk. J Am Coll Cardiol 2004;43:678–683.
  25. Desideri G, Croce G, Ferri C: Does nondipping blood pressure profile contribute to vascular inflammation during sleep deprivation? J Am Coll Cardiol 2004;44:1529–1530, author reply 1530–1531.

    External Resources

  26. Bonnet MH, Arand DL: Insomnia, metabolic rate and sleep restoration. J Intern Med 2003;254:23–31.
  27. Plazzi G, Schutz Y, Cortelli P, Provini F, Avoni P, Heikkila E, Tinuper P, Solieri L, Lugaresi E, Montagna P: Motor overactivity and loss of motor circadian rhythm in fatal familial insomnia: an actigraphic study. Sleep 1997;20:739–742.
  28. Helfand SL, Rogina B: From genes to aging in Drosophila. Adv Genet 2003;49:67–109.
  29. Shaw P, Ocorr K, Bodmer R, Oldham S: Drosophila aging 2006/2007. Exp Gerontol 2008;43:5–10.
  30. Hughes KA, Reynolds RM: Evolutionary and mechanistic theories of aging. Annu Rev Entomol 2005;50:421–445.
  31. Mair W, Goymer P, Pletcher SD, Partridge L: Demography of dietary restriction and death in Drosophila. Science 2003;301:1731–1733.
  32. Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, Sehgal A, Pack AI: Rest in Drosophila is a sleep-like state. Neuron 2000;25:129–138.
  33. Shaw PJ, Cirelli C, Greenspan RJ, Tononi G: Correlates of sleep and waking in Drosophila melanogaster. Science 2000;287:1834–1837.
  34. Cirelli C: The genetic and molecular regulation of sleep: from fruit flies to humans. Nat Rev Neurosci 2009;10:549–560.
  35. Bushey D, Cirelli C: From genetics to structure to function: exploring sleep in Drosophila. Int Rev Neurobiol 2011;99:213–244.

    External Resources

  36. Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, Tononi G: Reduced sleep in Drosophila Shaker mutants. Nature 2005;434:1087–1092.
  37. Bushey D, Huber R, Tononi G, Cirelli C: Drosophila hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci 2007;27:5384–5393.
  38. Bushey D, Hughes KA, Tononi G, Cirelli C: Sleep, aging, and lifespan in Drosophila. BMC Neurosci 2010;11:56.

    External Resources

  39. Ohayon MM, Carskadon MA, Guilleminault C, Vitiello MV: Meta-analysis of quantitative sleep parameters from childhood to old age in healthy individuals: developing normative sleep values across the human lifespan. Sleep 2004;27:1255–1273.
  40. Dijk DJ, Duffy JF, Czeisler CA: Contribution of circadian physiology and sleep homeostasis to age-related changes in human sleep. Chronobiol Int 2000;17:285–311.
  41. Gaudreau H, Carrier J, Montplaisir J: Age-related modifications of NREM sleep EEG: from childhood to middle age. J Sleep Res 2001;10:165–172.
  42. Steriade M, Timofeev I, Grenier F: Natural waking and sleep states: a view from inside neocortical neurons. J Neurophysiol 2001;85:1969–1985.
  43. Lopes da Silva F: Neural mechanisms underlying brain waves: from neural membranes to networks. Electroencephalogr Clin Neurophysiol 1991;79:81–93.
  44. Esser SK, Hill SL, Tononi G: Sleep homeostasis and cortical synchronization. I. Modeling the effects of synaptic strength on sleep slow waves. Sleep 2007;30:1617–1630.

    External Resources

  45. Riedner BA, Vyazovskiy VV, Huber R, Massimini M, Esser S, Murphy M, Tononi G: Sleep homeostasis and cortical synchronization. III. A high-density EEG study of sleep slow waves in humans. Sleep 2007;30:1643–1657.

    External Resources

  46. Vyazovskiy VV, Olcese U, Lazimy YM, Faraguna U, Esser SK, Williams JC, Cirelli C, Tononi G: Cortical firing and sleep homeostasis. Neuron 2009;63:865–878.
  47. Hanlon EC, Vyazovskiy VV, Ugo F, Tononi G, Cirelli C: Synaptic potentiation and sleep need: clues from molecular and electrophysiological studies. Curr Top Med Chem 2011;11:2472–2482.
  48. Tononi G, Cirelli C: Sleep function and synaptic homeostasis. Sleep Med Rev 2006;10:49–62.
  49. Ringli M, Huber R: Developmental aspects of sleep slow waves: linking sleep, brain maturation and behavior. Prog Brain Res 2011;193:63–82.

    External Resources

  50. Petanjek Z, Judas M, Simic G, Rasin MR, Uylings HB, Rakic P, Kostovic I: Extraordinary neoteny of synaptic spines in the human prefrontal cortex. Proc Natl Acad Sci USA 2011;108:13281–13286.
  51. Cajochen C, Munch M, Knoblauch V, Blatter K, Wirz-Justice A: Age-related changes in the circadian and homeostatic regulation of human sleep. Chronobiol Int 2006;23:461–474.
  52. Gaudreau H, Morettini J, Lavoie HB, Carrier J: Effects of a 25 h sleep deprivation on daytime sleep in the middle-aged. Neurobiol Aging 2001;22:461–468.