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Frontostriatal Connectivity in Children during Working Memory and the Effects of Prenatal Methamphetamine, Alcohol, and Polydrug Exposure

Roussotte F.F.a, b · Rudie J.D.c · Smith L.d · O’Connor M.J.c · Bookheimer S.Y.c · Narr K.L.e · Sowell E.R.a, b
aDevelopmental Cognitive Neuroimaging Laboratory, Children’s Hospital Los Angeles and Department of Pediatrics, University of Southern California, bUniversity of California, Los Angeles (UCLA), Department of Neurology, and cUCLA Department of Psychiatry and Biobehavioral Sciences, Los Angeles, Calif., dHarbor-UCLA Medical Center, Department of Pediatrics, Torrance, Calif., and eLaboratory of NeuroImaging, Department of Neurology, University of California, Los Angeles, Calif., USA Dev Neurosci 2012;34:43–57 (DOI:10.1159/000336242)

Abstract

Various abnormalities in frontal and striatal regions have been reported in children with prenatal alcohol and/or methamphetamine exposure. In a recent fMRI study, we observed a correlation between accuracy on a working-memory task and functional activation in the putamen in children with prenatal methamphetamine and polydrug exposure. Because the putamen is part of the corticostriatal motor loop whereas the caudate is involved in the executive loop, we hypothesized that a loss of segregation between distinct corticostriatal networks may occur in these participants. The current study was designed to test this hypothesis using functional connectivity MRI. We examined 50 children ranging in age from 7 to 15, including 19 with prenatal methamphetamine exposure (15 of whom had concomitant prenatal alcohol exposure), 13 with prenatal exposure to alcohol but not methamphetamine, and 18 unexposed controls. We measured the coupling between blood oxygenation level dependent (BOLD) fluctuations during a working-memory task in four striatal seed regions and those in the rest of the brain. We found that the putamen seeds showed increased connectivity with frontal brain regions involved in executive functions while the caudate seeds showed decreased connectivity with some of these regions in both groups of exposed subjects compared to controls. These findings suggest that localized brain abnormalities resulting from prenatal exposure to alcohol and/or methamphetamine lead to a partial rewiring of corticostriatal networks. These results represent important progress in the field, and could have substantial clinical significance in helping devise more targeted treatments and remediation strategies designed to better serve the needs of this population.

 

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