Cover

Allergy and the Nervous System

Editor(s): Bienenstock J. (Hamilton, Ont.) 
Table of Contents
Vol. 98, 2012
Section title: Paper
Bienenstock J (ed): Allergy and the Nervous System.Chem Immunol Allergy. Basel, Karger, 2012, vol 98, pp 253–265
(DOI:10.1159/000336529)

Itch and the Brain

Pfab F. · Valet M. · Napadow V. · Tölle T.-R. · Behrendt H. · Ring J. · Darsow U.
aDepartment of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Mass., USA; bDepartment of Dermatology and Allergy and cDepartment of Neurology, Klinikum r.d. Isar, Technische Universität München and dDivision of Environmental Dermatology and Allergy, Helmholtz Zentrum München/TUM, ZAUM-Center for Allergy and Environment, Munich, Germany

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Abstract

The sensation of itch – defined as unpleasant sensation inducing the urge to scratch – is processed by a network of different brain regions contributing to the encoding of sensory, emotional, attention-dependent, cognitive-evaluative and motivational patterns. Patients with atopic eczema show different activation patterns and kinetics compared to healthy volunteers. This review summarizes current studies investigating itch in the brain.



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References

  1. Mochizuki H, Sadato N, Saito DN, et al: Neural correlates of perceptual difference between itching and pain: a human fMRI study. NeuroImage 2007;36:706-717
  2. Leknes SG, Bantick S, Willis CM, Wilkinson JD, Wise RG, Tracey I: Itch and motivation to scratch: an investigation of the central and peripheral correlates of allergen- and histamine-induced itch in humans. J Neurophysiol 2007;97:415-22
  3. Mochizuki H, Inui K, Tanabe HC, et al: Time course of activity in itch-related brain regions: a combined MEG-fMRI study. J Neurophysiol 2009;102:2657-2666
  4. Pfab F, Valet M, Sprenger T, et al: Temperature modulated histamine-itch in lesional and nonlesional skin in atopic eczema - a combined psychophysical and neuroimaging study. Allergy 2010;65:84-94
  5. Elias PM, Hatano Y, Williams ML: Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J Allergy Clin Immunol 2008;121:1337-1343
  6. Sicherer SH, Leung DY: Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2007. J Allergy Clin Immunol 2008;121:1351-1358
  7. Schneider G, Stander S, Burgmer M, Driesch G, Heuft G, Weckesser M: Significant differences in central imaging of histamine-induced itch between atopic dermatitis and healthy subjects. Eur J Pain 2008;12:834-841
  8. Ishiuji Y, Coghill RC, Patel TS, Oshiro Y, Kraft RA, Yosipovitch G: Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis. Br J Dermatol 2009;161:1072-1080
  9. Singer T, Seymour B, O’Doherty J, Kaube H, Dolan RJ, Frith CD: Empathy for pain involves the affective but not sensory components of pain. Science 2004;303:1157-1162
  10. Gracely RH, Geisser ME, Giesecke T, et al: Pain catastrophizing and neural responses to pain among persons with fibromyalgia. Brain 2004;127:835-843
  11. Craig AD: Interoception: the sense of the physiological condition of the body. Curr Opin Neurobiol 2003;13:500-505
  12. Cunnington R, Windischberger C, Moser E: Premovement activity of the pre-supplementary motor area and the readiness for action: studies of time-resolved event-related functional MRI. Hum Mov Sci 2005;24:644-656
  13. Vogt BA: Pain and emotion interactions in subregions of the cingulate gyrus. Nat Rev 2005;6:533-544
  14. Kwan CL, Crawley AP, Mikulis DJ, Davis KD: An fMRI study of the anterior cingulate cortex and surrounding medial wall activations evoked by noxious cutaneous heat and cold stimuli. Pain 2000;85:359-374
  15. Tölle TR, Kaufmann T, Siessmeier T, et al: Region-specific encoding of sensory and affective components of pain in the human brain: a positron emission tomography correlation analysis. Ann Neurol 1999;45:40-47
  16. Buchel C, Bornhovd K, Quante M, Glauche V, Bromm B, Weiller C: Dissociable neural responses related to pain intensity, stimulus intensity, and stimulus awareness within the anterior cingulate cortex: a parametric single-trial laser functional magnetic resonance imaging study. J Neurosci 2002;22:970-976
  17. Apkarian AV, Bushnell MC, Treede RD, Zubieta JK: Human brain mechanisms of pain perception and regulation in health and disease. Eur J Pain 2005;9:463-484
  18. Freund HJ: The parietal lobe as a sensorimotor interface: a perspective from clinical and neuroim-aging data. NeuroImage 2001;14:142-146
  19. Fuster JM: The Prefrontal Cortex. Anatomy, Physiology and Neuropsychology of the Frontal Lobe. Philadelphia, Lippincott-Raven, 1997;
  20. Walter B, Sadlo MN, Kupfer J, et al: Brain activation by histamine prick test-induced itch. J Invest Dermatol 2005;125:380-382
  21. Hsieh JC, Hagermark O, Stahle-Backdahl M, et al: Urge to scratch represented in the human cerebral cortex during itch. J Neurophysiol 1994;72:3004-3008
  22. Drzezga A, Darsow U, Treede RD, et al: Central activation by histamine-induced itch: analogies to pain processing: a correlational analysis of 0-15 H2O positron emission tomography studies. Pain 2001;92:295-305
  23. Valet M, Pfab F, Sprenger T, et al: Cerebral processing of histamine-induced itch using short-term alternating temperature modulation - an fMRI study. J Invest Dermatol 2008;128:426-433
  24. Pfab F, Valet M, Sprenger T, et al: Short-term alternating temperature enhances histamine-induced itch: a biphasic stimulus model. J Invest Dermatol 2006;126:2673-2678
  25. Mochizuki H, Tashiro M, Kano M, Sakurada Y, Itoh M, Yanai K: Imaging of central itch modulation in the human brain using positron emission tomography. Pain 2003;105:339-346
  26. Sprenger T, Ruether K, Boecker H, et al: Altered metabolism in frontal brain circuits in cluster headache. Cephalalgia 2007;27:1033-1042
  27. Ikoma A, Steinhoff M, Stander S, Yosipovitch G, Schmelz M: The neurobiology of itch. Nat Rev 2006;7:535-547
  28. Schmelz M, Schmidt R, Bickel A, Handwerker HO, Torebjoerk HE: Specific C-receptors for itch in human skin. J Neurosci 1997;17:8003-8008
  29. Darsow U, Drzezga A, Frisch M, et al: Processing of histamine-induced itch in the human cerebral cortex: a correlation analysis with dermal reactions. I Invest Dermatol 2000;115:1029-1033
  30. Darsow U, Ring J, Scharein E, Bromm B: Correlations between histamine-induced wheal, flare and itch. Arch Dermatol Res 1996;288:436-441
  31. Pfab F, Hammes M, Backer M, et al: Preventive effect of acupuncture on histamine-induced itch: a blinded, randomized, placebo-controlled, crossover trial. J Allergy Clin Immunol 2005;116:1386-1388
  32. Darsow U, Scharein E, Simon D, Walter G, Bromm B, Ring J: New aspects of itch pathophysiology: component analysis of atopic itch using the ‘Eppendorf Itch Questionaire’. Int Arch Allergy Immunol 2001;124:326-331
  33. Stander S, Weisshaar E, Mettang T, et al: Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Dermato-venereol 2007;87:291-294
  34. Behrendt H, Krämer U, Schäfer T, et al: Allergotoxicology - a research concept to study the role of environmental pollutants in allergy. ACI Int 2001;13:122-128
  35. Charlesworth EN, Beltrani VS: Pruritic dermatoses: overview of etiology and therapy. Am J Med 2002;113:(suppl 9A)25S-33S
  36. Hafenreffer S: (eds) In Kuhnen B: De pruritu, in Nosodochium, in quo cutis, eique adaerentium partium, affectus omnes, singulari methodo, et cognoscendi et curandi fidelissime traduntur. Ulm 1660;98-102


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