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Vol. 31, No. 4, 2012
Issue release date: June 2012
Section title: Original Paper
Fetal Diagn Ther 2012;31:216–220
(DOI:10.1159/000336692)

Maternal Hemodynamics at 11–13 Weeks’ Gestation in Gestational Diabetes Mellitus

Khalil A. · Garcia-Mandujano R. · Chiriac R. · Akolekar R. · Nicolaides K.H.
aDepartment of Fetal Medicine, Institute for Women’s Health, University College London Hospitals, and bDepartment of Fetal Medicine, King’s College Hospital, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/2/2011 11:36:01 AM
Accepted: 1/3/2012
Published online: 5/3/2012

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: Women who develop gestational diabetes mellitus (GDM) are at increased risk of type 2 diabetes and subsequent cardiovascular mortality and morbidity. Individuals with cardiovascular disorders have increased central aortic systolic blood pressure (SBPAo) and arterial stiffness. The hypothesis of this study is that increased SBPAo and arterial stiffness are apparent before the development of GDM. Methods: In this screening study, SBPAo, pulse wave velocity (PWV) and augmentation index (AIx) were measured in women with singleton pregnancies attending for routine antenatal care at 11–13 weeks’ gestation. We compared SBPAo, PWV and AIx, expressed as multiples of the median (MoM), after adjustment for maternal characteristics affecting these measurements, in women who subsequently developed GDM (n = 105) with the values in non-GDM controls (n = 6,736). Results: In the GDM group, compared to non-GDM controls, there was an increase in PWV [1.04 MoM, interquartile range (IQR) 0.93–1.15 vs. 1.00 MoM, IQR 0.90–1.12; p = 0.013] and SBPAo (1.03 MoM, IQR 0.98–1.14 vs. 1.00 MoM, IQR 0.94–1.08; p < 0.0001) but no significant difference in the AIx (1.02 MoM, IQR 0.89–1.22 vs. 1.00 MoM, IQR 0.87–1.17; p = 0.118). Conclusion: Women who develop GDM have increased SBPAo and arterial stiffness from the first trimester of pregnancy before the clinical onset of GDM.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/2/2011 11:36:01 AM
Accepted: 1/3/2012
Published online: 5/3/2012

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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