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Vol. 85, No. 4, 2012
Issue release date: June 2012
Section title: Original Paper
Digestion 2012;85:295–301
(DOI:10.1159/000336719)

Clinical Features and Management of Parastomal Pyoderma Gangrenosum in Inflammatory Bowel Disease

Uchino M. · Ikeuchi H. · Matsuoka H. · Bando T. · Takahashi Y. · Takesue Y. · Matsumoto T. · Tomita N.
aDepartment of Surgery, bDivision of Infection Control and Prevention, and cDivision of Lower Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/8/2011 11:26:34 AM
Accepted: 1/19/2012
Published online: 5/12/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 5

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG

Abstract

Background: Pyoderma gangrenosum (PG) is often associated with inflammatory bowel disease even after bowel surgery, but it remains an extremely rare pathology. The purpose of this study was to investigate the clinical features and treatment of PG and to consider proper management for peristomal PG. Methods: Demographic data for patients who underwent colorectal surgery with ostomy creation at Hyogo College of Medicine between July 2007 and July 2011 were prospectively collected. The main outcome measures were postoperative occurrence of peristomal PG by type: explosive and rapidly spreading type (type R) and indolent and gradually spreading type (type G). Results: Overall prevalence was 11/738 (1.5%), with type R in 5 patients and type G in 6. Type R and type G were significantly more common in ulcerative colitis and Crohn’s disease, respectively (p = 0.01). Type R developed within 6 days after surgery. Type G developed a mean of 52 days after surgery. Complete healing required a long time in both types, with means of 69 days for type R and 48 days for type G. Conclusion: Although peristomal PG was a rare complication after surgery, differences in the development of PG were observed between ulcerative colitis and Crohn’s disease. Careful observation and knowledge of PG are needed.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/8/2011 11:26:34 AM
Accepted: 1/19/2012
Published online: 5/12/2012

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 5

ISSN: 0012-2823 (Print)
eISSN: 1421-9867 (Online)

For additional information: http://www.karger.com/DIG


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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