Table of Contents
To view the fulltext, log-in or choose pay-per-view options:
Get Access

The Association between Physical Morbidity and Subtypes of Severe Depression

Østergaard S.D.a · Petrides G.d · Dinesen P.T.b · Skadhede S.a · Bech P.c · Munk-Jørgensen P.a · Nielsen J.a
aUnit for Psychiatric Research, Aalborg Psychiatric Hospital, Aarhus University Hospital, Aalborg, bDepartment of Political Science, University of Copenhagen, Copenhagen, and cPsychiatric Research Unit, Psychiatric Center Nordsjælland, Copenhagen University Hospital, Hillerød, Denmark; dZucker Hillside Hospital, Northshore-LIJ Health System, Glen Oaks, N.Y., USA Psychother Psychosom 2013;82:45–52 (DOI:10.1159/000337746)


Background: Physical illness and depression are related, but the association between specific physical diseases and diagnostic subtypes of depression remains poorly understood. This study aimed to clarify the relationship between a number of physical diseases and the nonpsychotic and psychotic subtype of severe depression. Methods: This is a historical prospective cohort study. The study population consisted of all patients diagnosed with ICD-10 severe depression, either nonpsychotic or psychotic subtype, in Danish psychiatric hospitals between 1994 and 2008. The patients’ history of physical disease was assessed using the Danish National Patient Register. Using logistic regression it was investigated whether specific physical diseases were associated with relative increased risk for subsequent development of either the nonpsychotic or psychotic depressive subtype. Results: A total of 24,173 patients with severe depression were included in the study. Of those, 8,260 (34%) were of the psychotic subtype. A history of the following physical diseases, as opposed to their absence, increased the relative risk for subsequent development of the nonpsychotic compared to the psychotic depressive subtype [adjusted incidence odds ratio (AIOR) nonpsychotic vs. psychotic]: ischemic heart disease (AIOR = 1.3, p < 0.001), hypertension (AIOR = 1.2, p = 0.008), stroke (AIOR = 1.2, p = 0.042) and chronic lower pulmonary disease (AIOR = 1.2, p = 0.005). The total load of physical disease also increased the relative risk of nonpsychotic depression [AIOR = 1.05 (per disease), p = 0.001]. Conclusions: This study revealed that, in severe depression, a history of physical disease increased the relative risk of the nonpsychotic rather than the psychotic subtype.


Individual Users: Register with Karger Login Information

Please create your User ID & Password

Contact Information

I have read the Karger Terms and Conditions and agree.

Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50