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Table of Contents
Vol. 102, No. 2, 2012
Issue release date: August 2012
Section title: Commentary
Neonatology 2012;102:137–138
(DOI:10.1159/000339112)

Judgment Often Impossible without Randomized Trials

Commentary on N. Patel: Use of Milrinone to Treat Cardiac Dysfunction in Infants with Pulmonary Hypertension Secondary to Congenital Diaphragmatic Hernia: A Review of Six Patients (Neonatology 2012;102:130–136)

Giaccone A. · Kirpalani H.
Division of Neonatology, The Children’s Hospital of Philadelphia, Philadelphia, Pa., USA

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Article / Publication Details

Received: 4/3/2012
Accepted: 4/10/2012
Published online: 6/16/2012

Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


First-Page Preview
Abstract of Commentary

Article / Publication Details

Received: 4/3/2012
Accepted: 4/10/2012
Published online: 6/16/2012

Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

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  2. Danhaive O, Margossian R, Geva T, Kourembanas S: Pulmonary hypertension and right ventricular dysfunction in growth-restricted, extremely low birth weight neonates. J Perinatol 2005;25:495-49-9.
  3. Bassler D, Choong K, McNamara P, Kirpalani H: Neonatal persistent pulmonary hypertension treated with milrinone: four case reports. Biol Neonate 2006;89:1–5.
  4. McNamara PJ, Laique F, Muang-In S, Whyte HE: Milrinone improves oxygenation in neonates with severe persistent pulmonary hypertension of the newborn. J Crit Care 2006;21:217–222.
  5. Tzialla C, Cerbo RM, Perotti G, Stronati M: Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide-treated with milrinone: a case report. Turk J Pediatr 2010;52:78–80.

    External Resources

  6. Sehgal A, Francis JV, Lewis AI: Use of milrinone in the management of haemodynamic instability following duct ligation. Eur J Pediatr 2011;170:115–119.
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  12. Hoffman TM, Wernovsky G, Atz AM, et al: Efficacy and safety of milrinone in preventing low cardiac output syndrome in infants and children after corrective surgery for congenital heart disease. Circulation 2003;107:996–1002.
  13. Barton P, Garcia J, Kouatli A, et al: Hemodynamic effects of i.v. milrinone lactate in pediatric patients with septic shock. A prospective, double-blinded, randomized, placebo-controlled, interventional study. Chest 1996;109:1302–1312.
  14. Paradisis M, Evans N, Kluckow M, Osborn D: Randomized trial of milrinone versus placebo for prevention of low systemic blood flow in very preterm infants. J Pediatr 2009;154:189–195.
  15. Pasquali SK, Hall M, Slonim AD, et al: Off-label use of cardiovascular medications in children hospitalized with congenital and acquired heart disease. Circ Cardiovasc Qual Outcomes 2008;1:74–83.

    External Resources

  16. Chiu PP, Sauer C, Mihailovic A, Adatia I, Bohn D, Coates AL, Langer JC: The price of success in the management of congenital diaphragmatic hernia: is improved survival accompanied by an increase in long-term morbidity? J Pediatr Surg 2006;41:888–892.

    External Resources

  17. van den Hout L, Schaible T, Cohen-Overbeek TE, Hop W, Siemer J, van de Ven K, Wessel L, Tibboel D, Reiss I: Actual outcome in infants with congenital diaphragmatic hernia: the role of a standardized postnatal treatment protocol. Fetal Diagn Ther 2011;29:55–63.
  18. Kotecha S, Barbato A, Bush A, Claus F, Davenport M, Delacourt C, Deprest J, Eber E, Frenckner B, Greenough A, Nicholson A, Antón-Pacheco JL, Midulla F: Congenital diaphragmatic hernia. Eur Respir J 2012;39:820–829.
  19. van den Hout L, Tibboel D, Vijfhuize S, te Beest H, Hop W, Reiss I, CDH-EURO Consortium: The VICI-trial: high frequency oscillation versus conventional mechanical ventilation in newborns with congenital diaphragmatic hernia: an international multicentre randomized controlled trial. BMC Pediatr 2011;11:98.

    External Resources

  20. Demauro SB, Giaccone A, Kirpalani H, Schmidt B: Quality of reporting of neonatal and infant trials in high-impact journals. Pediatrics 2011;128:e639–e644.

    External Resources