Delay Discounting of Reward and Caudate Nucleus Volume in Individuals with α-Synuclein Gene Duplication before and after the Development of Parkinson’s DiseaseSzamosi A.a · Nagy H.b, c · Kéri S.a, d
aNational Psychiatry Center, bNational Institute for Medical Rehabilitation, and cDepartment of Neurology, Semmelweis University, Budapest, and dDepartment of Physiology, Faculty of Medicine, University of Szeged, Szeged, Hungary Neurodegenerative Dis 2013;11:72–78 (DOI:10.1159/000341997)
Background/Aims: α-Synuclein (SNCA) may be a key factor in dopaminergic neurotransmission, reward processing, and neurodegeneration in Parkinson’s disease (PD). We investigated delay discounting of reward and caudate volume in SNCA gene duplication carriers before and after the development of PD. Methods: Participants were 7 presymptomatic SNCA duplication carriers who later developed PD (follow-up period: 5.4 years) and 10 matched non-carrier controls. At the follow-up assessment, patients received levodopa (
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