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7, No. 4, 2012
Issue release date: August 2012
Section title: Review Article · Übersichtsarbeit
Free Access
Breast Care 2012;7:267–272
(DOI:10.1159/000342166)

Immunomodulation via Chemotherapy and Targeted Therapy: A New Paradigm in Breast Cancer Therapy?

Stagg J.a · Andre F.b · Loi S.c
aCentre de Recherche du Centre Hospitalier de l’Université de Montréal, Faculté de Pharmacie et Institut du Cancer de Montréal, Montréal, Québec, Canada bINSERM Unit 981, Department of Medical Oncology, Institut Gustave Roussy, Villejuif, France cBreast Cancer Translational Research Laboratory (BCTL), Institut Jules Bordet, Brussels, Belgium
email Corresponding Author

Abstract

Cytotoxic chemotherapy in the treatment of tumors has traditionally been thought to be immunosuppressive. Increasing evidence suggests the contrary and has introduced the concept of ‘immunogenic’ chemotherapy or, in other words, the concept that the innate and adaptive immune systems are critical in determining the longterm efficacy of some cytotoxic-based (and radiotherapy-based) regimens. The underlying mechanisms how these therapies can stimulate an antitumor immune response have been demonstrated recently. In this article, we review the background of this new paradigm and how combinations of traditional agents with the new immunotherapeutic therapies may significantly advance our treatment of breast cancer.

© 2012 S. Karger AG, Basel


  

Keywords

  • Breast cancer
  • Tumor-infiltrating lymphocytes
  • Prognosis
  • Immunotherapy

  

Author Contacts

Dr. Sherene Loi, MD, PhD
Breast Cancer Translational Research Laboratory (BCTL)
Institut Jules Bordet
Boulevard de Waterloo 121, Brussels B1000, Belgium
Tel. +32 2 541-3457/3107, Fax -3199
sherene.loi@bordet.be

  

Article Information

Published online: August 13, 2012
Number of Print Pages : 6

  

Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 7, No. 4, Year 2012 (Cover Date: August 2012)

Journal Editor: Harbeck N. (München), Thomssen C. (Halle/Saale), Gnant M. (Wien)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

Abstract

Cytotoxic chemotherapy in the treatment of tumors has traditionally been thought to be immunosuppressive. Increasing evidence suggests the contrary and has introduced the concept of ‘immunogenic’ chemotherapy or, in other words, the concept that the innate and adaptive immune systems are critical in determining the longterm efficacy of some cytotoxic-based (and radiotherapy-based) regimens. The underlying mechanisms how these therapies can stimulate an antitumor immune response have been demonstrated recently. In this article, we review the background of this new paradigm and how combinations of traditional agents with the new immunotherapeutic therapies may significantly advance our treatment of breast cancer.

© 2012 S. Karger AG, Basel


  

Author Contacts

Dr. Sherene Loi, MD, PhD
Breast Cancer Translational Research Laboratory (BCTL)
Institut Jules Bordet
Boulevard de Waterloo 121, Brussels B1000, Belgium
Tel. +32 2 541-3457/3107, Fax -3199
sherene.loi@bordet.be

  

Article Information

Published online: August 13, 2012
Number of Print Pages : 6

  

Publication Details

Breast Care (Multidisciplinary Journal for Research, Diagnosis and Therapy)

Vol. 7, No. 4, Year 2012 (Cover Date: August 2012)

Journal Editor: Harbeck N. (München), Thomssen C. (Halle/Saale), Gnant M. (Wien)
ISSN: 1661-3791 (Print), eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


Article / Publication Details

First-Page Preview
Abstract of Review Article · Übersichtsarbeit

Published online: 8/13/2012
Issue release date: August 2012

Number of Print Pages: 0
Number of Figures: 0
Number of Tables: 0

ISSN: 1661-3791 (Print)
eISSN: 1661-3805 (Online)

For additional information: http://www.karger.com/BRC


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.