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Vol. 57, No. 1, 2013
Issue release date: January–February
Section title: Fine Needle Aspiration
Acta Cytologica 2013;57:19–25
(DOI:10.1159/000342574)

Lymphoproliferative Disorders of the Kidney on Fine-Needle Aspiration: Cytomorphology and Radiographic Correlates in 33 Cases

Subhawong A.P. · Subhawong T.K. · VandenBussche C.J. · Siddiqui M.T. · Ali S.Z.
Departments of aPathology and bRadiology, The Johns Hopkins School of Medicine, Baltimore, Md., and cDepartment of Pathology, Emory School of Medicine, Atlanta, Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Fine Needle Aspiration

Received: 6/20/2012 11:17:29 AM
Accepted: 8/9/2012
Published online: 12/6/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

Abstract

Background: Unless renal lesions present in the setting of widespread lymphoma, biopsy can be indicated to differentiate from metastases, hypovascular renal cell carcinoma, urothelial carcinoma or infection. We review our experience with lymphoproliferative disorders in the kidney diagnosed by fine-needle aspiration (FNA), and focus on clinicopathologic and radiographic features. Design: All cases of non-Hodgkin lymphoma diagnosed on renal FNA at 2 academic institutions between 1989 and 2011 were reviewed. Clinical history, radiographic and cytomorphologic features, and follow-up were assessed. Results: 33 cases were identified, with 15 primary tumors and 18 recurrences/secondary tumors including 1 acute lymphoblastic lymphoma. The majority were aggressive/high-grade lesions (25/33). 25 cases were substantiated by positive flow cytometry results. Most were detected at follow-up/incidentally. 22 cases showed multiple renal and/or retroperitoneal masses or a significant component of adenopathy; others showed a solitary renal mass. Salient radiologic features included hypodense, infiltrative and ill-defined masses. Cytomorphology showed a monotonous population of large atypical lymphoid cells, often with lymphoglandular bodies. Conclusion: Cytologic diagnosis of renal lymphoma requires analysis of morphological, clinical and immunophenotypic information. Helpful features for diagnosis include: multiple masses on computed tomography, a monotonous population of abnormal cells in a background of lymphoglandular bodies and immunophenotyping demonstrating light chain restriction.


Article / Publication Details

First-Page Preview
Abstract of Fine Needle Aspiration

Received: 6/20/2012 11:17:29 AM
Accepted: 8/9/2012
Published online: 12/6/2012

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 1

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Morel P, Dupriez B, Herbrecht R, Bastion Y, Tilly H, Delannoy A, Haioun C, Nouvel C, Bouabdallah K, Baumelou E, et al: Aggressive lymphomas with renal involvement: a study of 48 patients treated with the LNH-84 and LNH-87 regimens. Groupe d’Etude des Lymphomes de l’Adulte. Br J Cancer 1994;70:154–159.
  2. Sheth S, Ali S, Fishman E: Imaging of renal lymphoma: patterns of disease with pathologic correlation. Radiographics 2006;26:1151–1168.
  3. Murphy WM, Zambroni BR, Emerson LD, Moinuddin S, Lee LH: Aspiration biopsy of the kidney: simultaneous collection of cytologic and histologic specimens. Cancer 1985;56:200–205.
  4. Truong LD, Todd TD, Dhurandhar B, Ramzy I: Fine-needle aspiration of renal masses in adults: analysis of results and diagnostic problems in 108 cases. Diagn Cytopathol 1999;20:339–349.
  5. Gattuso P, Ramzy I, Truong LD, Lankford KL, Green L, Kluskens L, Spitz DJ, Reddy VB: Utilization of fine-needle aspiration in the diagnosis of metastatic tumors to the kidney. Diagn Cytopathol 1999;21:35–38.
  6. Truong LD, Caraway N, Ngo T, Laucirica R, Katz R, Ramzy I: Renal lymphoma: the diagnostic and therapeutic roles of fine-needle aspiration. Am J Clin Pathol 2001;115:18–31.
  7. Dekmezian RH, Charnsangavej C, Rava P, et al: Fine needle aspiration of kidney tumors in 105 patients: a cytologic and histologic correlation. Acta Cytol 1985;29:931.

    External Resources

  8. Murphy WM, Zambroni BR, Emerson LD, Moinuddin S, Lee LH: Aspiration biopsy of the kidney: simultaneous collection of cytologic and histologic specimens. Cancer 1985;56:200–205.
  9. Kelley CM, Cohen MB, Raab SS: Utility of fine-needle aspiration biopsy in solid renal masses. Diagn Cytopathol 1996;14:14–19.
  10. Ferry JA, Harris NL, Papanicolaou N, Young RH: Lymphoma of the kidney: a report of 11 cases. Am J Surg Pathol 1995;19:134–144.
  11. Osborne BM, Brenner M, Weitzner S, Butler JJ: Malignant lymphoma presenting as a renal mass: four cases. Am J Surg Pathol 1987;11:375–382.
  12. Arranz Arija JA, Carrion JR, Garcia FR, Tejedor A, Pérez-Manga G, Tardio J, Menarguez FJ: Primary renal lymphoma: report of 3 cases and review of the literature. Am J Nephrol 1994;14:148–153.
  13. Kose F, Sakalli H, Mertsoylu H, Sezer A, Kocer E, Tokmak N, Kilinc F, Ozyilkan O: Primary renal lymphoma: report of four cases. Onkologie 2009;32:200–202.
  14. Stallone G, Infante B, Manno C, Campobasso N, Pannarale G, Schena FP: Primary renal lymphoma does exist: case report and review of the literature. J Nephrol 2000;13:367–372.
  15. Karadeniz C, Oguz A, Ataoglu O, Citak C, Buyan N, Pinarli G, Ozkaya O, Kapucu O: Primary renal lymphoma and xanthogranulomatous pyelo-nephritis in childhood. J Nephrol 2002;15:597–600.
  16. Cupisti A, Riccioni R, Carulli G, Paoletti S, Tognetti A, Meola M, Francesca F, Barsotti G, Petrini M: Bilateral primary renal lymphoma treated by surgery and chemotherapy. Nephrol Dial Transplant 2004;19:1629–1633.
  17. Chatzipantelis P, Mastorakis E, Tzortzakakis D, Salla C: Fine needle aspiration cytology diagnosis of primary renal lymphoma involving the pleura: a case report. Acta Cytol 2010;54:71–74.
  18. Balestreri L, Morassut S, Bernardi D, Tavio M, Talamini R, Gloghini A, Carbone A: Efficacy of CT-guided percutaneous needle biopsy in the diagnosis of malignant lymphoma at first presentation. Imaging 2005;29:123–127.
  19. Anderson CM, Pusztai L, Palmer JL, Cabanillas F, Ellerhorst JA: Coincident renal cell carcinoma and non-Hodgkin’s lymphoma: the M.D. Anderson experience and review of the literature. J Urol 1998;159:714–717.
  20. Trpkov K, Marcussen N, Rayner D, Lam G, Solez K: Kidney allograft with a lymphocytic infiltrate: acute rejection, posttransplantation lymphoproliferative disorder, neither, or both entities? Am J Kidney Dis 1997;30:449–454.
  21. Renshaw AA, Granter SR, Cibas ES: Fine needle aspiration of the adult kidney. Cancer 1997;81:71–88.
  22. LeMeur Y, Potelune N, Jaccard A, Petit B, Bordessoule D, Peyronnet P, Ranger S, Labrousse F, Leroux-Robert C: Lymphoproliferative syndromes after renal transplantation (in French). Nephrologie 1998;19:255–261.
  23. Gattuso P, Reddy VB, Kizilbash N, Kluskens L, Selvaggi SM: Role of fine-needle aspiration in the clinical management of solid organ transplant recipients: a review. Cancer 1999;87:286–294.
  24. Siddiqui MT, Reddy VB, Castelli MJ, Gattuso P: Role of fine needle aspiration in clinical management of transplant patients. Diagn Cytopathol 1997;17:429–435.
  25. Gattuso P, Manosca F: Fine-needle aspiration of posttransplant lymphoproliferative disorders: a review. Diagn Cytopathol 2005;33:273–278.