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Table of Contents
Vol. 34, No. 4, 2012
Issue release date: November 2012
Section title: Original Paper
Cerebrovasc Dis 2012;34:263–271
(DOI:10.1159/000342668)

Effects of Age on Outcome in the SENTIS Trial: Better Outcomes in Elderly Patients

Leker R.R. · Molina C. · Cockroft K. · Liebeskind D.S. · Concha M. · Shuaib A. · De Deyn P.P. · Burgin W.S. · Gupta R. · Dillon W. · Diener H.-C.
aHadassah-Hebrew University Medical Center, Jerusalem, Israel; bVall d´Hebron University Hospital, Barcelona, Spain; cPenn State Hershey Medical Center, Hershey, Pa., dUniversity of California Los Angeles, Los Angeles, Calif., eUniversity of California San Francisco, San Francisco, Calif., fSarasota Memorial Hospital, Sarasota, Fla., gUniversity of South Florida, Tampa, Fla., and hEmory University, Atlanta, Ga., USA; iUniversity of Alberta, Edmonton, Alta., Canada; jZNA Middelheim, Antwerpen, Belgium; Department of Neurology, UMCG Groningen, Groningen, The Netherlands; kUniversity Hospital Essen, Essen, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/14/2012 1:44:29 PM
Accepted: 8/13/2012
Published online: 3/7/2013 2:58:20 PM

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Increasing age is associated with poor outcome after stroke. The Safety and Efficacy of NeuroFlo Technology in Ischemic Stroke (SENTIS) trial explored the augmentation of collateral circulation to the ischemic penumbra as a novel approach to stroke treatment. The aim of this post hoc analysis was to examine the effect of age on outcomes in the SENTIS trial. Methods: Using data from the randomized controlled SENTIS trial, we explored outcomes of cerebral blood flow augmentation using the NeuroFlo™ device in patients categorized by age strata at 70 and 80 years. We evaluated outcomes of overall serious adverse event (SAE) and intracerebral hemorrhage (ICH) rates, freedom from all-cause and stroke-related mortality, and independent functional outcome as defined by the modified Rankin Scale score (mRS ≤2). Results: The SENTIS as-treated cohort included 251 patients ≥70 years and 107 patients ≥80 years. Elderly SENTIS patients included a higher percentage of women and Caucasians than the younger group. Patients in the older group more frequently had vascular risk factors including hypertension, previous stroke, transient ischemic attacks and atrial fibrillation. However, baseline risk-factor profile, stroke severity, and time to randomization did not differ between the treated and nontreated elderly patients. The older patients treated with NeuroFlo had significantly higher chances for survival and for obtaining an independent functional state (mRS ≤2) compared with those who were not treated. Rates of SAEs and ICHs did not differ between the treatment groups. Conclusions: NeuroFlo treatment is safe and results in better outcomes for elderly patients. This may be the result of recruitment and support of already existing collateral systems in these patients.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/14/2012 1:44:29 PM
Accepted: 8/13/2012
Published online: 3/7/2013 2:58:20 PM

Number of Print Pages: 9
Number of Figures: 4
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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