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Vol. 74, No. 1, 2012
Issue release date: November 2012
Section title: Original Paper
Free Access
Hum Hered 2012;74:1–11

Evaluation of a Bayesian Model Integration-Based Method for Censored Data

Hou L.a · Wang K.b · Bartlett C.W.a
aBattelle Center for Mathematical Medicine, The Research Institute at Nationwide Children’s Hospital and Department of Pediatrics, The Ohio State University, Columbus, Ohio, and bDepartment of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA
email Corresponding Author

Assist. Prof. Christopher W. Bartlett, PhD

Battelle Center for Mathematical Medicine, The Research Institute

Nationwide Children’s Hospital and The Ohio State University

JW3926, 700 Children’s Drive, Columbus, OH 43205 (USA)



  1. Tobin MD, Sheehan NA, Scurrah KJ, Burton PR: Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure. Stat Med 2005;24:2911–2935.
  2. Sillanpaa MJ, Hoti F: Mapping quantitative trait loci from a single-tail sample of the phenotype distribution including survival data. Genetics 2007;177:2361–2377.
  3. Li M, Boehnke M, Abecasis GR, Song PX: Quantitative trait linkage analysis using Gaussian copulas. Genetics 2006;173:2317–2327.
  4. Diao G, Lin DY: Semiparametric variance-component models for linkage and association analyses of censored trait data. Genet Epidemiol 2006;30:570–581.
  5. Anderson CA, McRae AF, Visscher PM: A simple linear regression method for quantitative trait loci linkage analysis with censored observations. Genetics 2006;173:1735–1745.
  6. Diao G, Lin DY: Semiparametric methods for mapping quantitative trait loci with censored data. Biometrics 2005;61:789–798.
    External Resources
  7. Epstein MP, Lin X, Boehnke M: A tobit variance-component method for linkage analysis of censored trait data. Am J Hum Genet 2003;72:611–620.
  8. Palmer LJ, Tiller KJ, Burton PR: Genome-wide linkage analysis using genetic variance components of alcohol dependency-associated censored and continuous traits. Genet Epidemiol 1999;17(suppl 1):S283–S288.
    External Resources
  9. Cui JS, Hopper JL, Harrap SB: Antihypertensive treatments obscure familial contributions to blood pressure variation. Hypertension 2003;41:207–210.
  10. Puppala S, Coletta DK, Schneider J, Hu SL, Farook VS, Dyer TD, Arya R, Blangero J, Duggirala R, DeFronzo RA, Jenkinson CP: Genome-wide linkage screen for systolic blood pressure in the Veterans Administration Genetic Epidemiology Study (VAGES) of Mexican-Americans and confirmation of a major susceptibility locus on chromosome 6q14.1. Hum Hered 2011;71:1–10.
  11. Schafer JL: Multiple imputation: a primer. Stat Methods Med Res 1999;8:3–15.
  12. Donders AR, van der Heijden GJ, Stijnen T, Moons KG: Review: a gentle introduction to imputation of missing values. J Clin Epidemiol 2006;59:1087–1091.
  13. Bartlett CW, Vieland VJ: Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families. BMC Genet 2005;6(suppl 1):S121.
  14. Wright S: An analysis of variability in the number of digits in an inbred strain of guinea pigs. Genetics 1934;19:506–536.
  15. Vieland VJ, Huang Y, Seok SC, Burian J, Catalyurek U, O’Connell J, Segre A, Valentine-Cooper W: KELVIN: a software package for rigorous measurement of statistical evidence in human genetics. Hum Hered 2011;72:276–288.
  16. Bartlett CW, Flax JF, Logue MW, Smith BJ, Vieland VJ, Tallal P, Brzustowicz LM: Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Hum Hered 2004;57:10–20.
  17. Vieland VJ, Hallmayer J, Huang Y, Pagnamenta AT, Pinto D, Khan H, Monaco AP, Paterson AD, Scherer SW, Sutcliffe JS, Szatmari P: Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. J Neurodev Disord 2011;3:113–123.
  18. Simmons TR, Flax JF, Azaro MA, Hayter JE, Justice LM, Petrill SA, Bassett AS, Tallal P, Brzustowicz LM, Bartlett CW: Increasing genotype-phenotype model determinism: application to bivariate reading/language traits and epistatic interactions in language-impaired families. Hum Hered 2010;70:232–244.
    External Resources
  19. Wratten NS, Memoli H, Huang Y, Dulencin AM, Matteson PG, Cornacchia MA, Azaro MA, Messenger J, Hayter JE, Bassett AS, Buyske S, Millonig JH, Vieland VJ, Brzustowicz LM: Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am J Psychiatry 2009;166:434–441.
  20. Vieland VJ: Bayesian linkage analysis, or: how I learned to stop worrying and love the posterior probability of linkage. Am J Hum Genet 1998;63:947–954.
  21. Bartlett CW, Flax JF, Logue MW, Vieland VJ, Bassett AS, Tallal P, Brzustowicz LM: A major susceptibility locus for specific language impairment is located on 13q21. Am J Hum Genet 2002;71:45–55.
  22. Logue MW, Vieland VJ, Goedken RJ, Crowe RR: Bayesian analysis of a previously published genome screen for panic disorder reveals new and compelling evidence for linkage to chromosome 7. Am J Med Genet B Neuropsychiatr Genet 2003;121B:95–99.
  23. Vieland VJ, Wang K, Huang J: Power to detect linkage based on multiple sets of data in the presence of locus heterogeneity: comparative evaluation of model-based linkage methods for affected sib pair data. Hum Hered 2001;51:199–208.
  24. Wang K, Huang J, Vieland VJ: The consistency of the posterior probability of linkage. Ann Hum Genet 2000;64:533–553.
  25. Ott J: Analysis of Human Genetic Linkage, ed 3. Baltimore, Johns Hopkins University Press, 1999.
  26. Bartlett CW, Vieland VJ: Accumulating quantitative trait linkage evidence across multiple datasets using the posterior probability of linkage. Genet Epidemiol 2007;31:91–102.
  27. Allison DB, Neale MC, Zannolli R, Schork NJ, Amos CI, Blangero J: Testing the robustness of the likelihood-ratio test in a variance-component quantitative-trait loci-mapping procedure. Am J Hum Genet 1999;65:531–544.
  28. Sham PC, Purcell S, Cherny SS, Abecasis GR: Powerful regression-based quantitative-trait linkage analysis of general pedigrees. Am J Hum Genet 2002;71:238–253.
  29. Vieland VJ, Huang Y, Bartlett C, Davies TF, Tomer Y: A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications. Am J Hum Genet 2008;82:1349–1356.
  30. Almasy L, Blangero J: Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 1998;62:1198–1211.
  31. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: Merlin – rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002;30:97–101.
  32. Tang HK, Siegmund D: Mapping quantitative trait loci in oligogenic models. Biostatistics 2001;2:147–162.
  33. Peng J, Siegmund D: Mapping quantitative traits with random and with ascertained sibships. Proc Natl Acad Sci USA 2004;101:7845–7850.