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Vol. 30, Suppl. 3, 2012
Issue release date: January 2013
Dig Dis 2012;30(suppl 3):112–118

Methotrexate: Underused and Ignored?

Herfarth H.H. · Long M.D. · Isaacs K.L.
Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, N.C., USA

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For more than a decade, methotrexate has been known to be an effective therapeutic agent in the treatment of steroid-dependent active Crohn’s disease. However, international data on medication utilization suggest that this drug is rarely used in clinical practice for an indication of Crohn’s disease. This review investigates the potential reasons for the underuse of methotrexate in patients with inflammatory bowel diseases.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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