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Table of Contents
Vol. 58, No. 4, 2012
Issue release date: November 2012
Section title: Clinical Study
Chemotherapy 2012;58:313–320
(DOI:10.1159/000343048)

Pemetrexed for Previously Treated Patients with Non-Small Cell Lung Cancer and Differences in Efficacy according to Thymidylate Synthase Expression

Igawa S. · Ryuge S. · Wada M. · Otani S. · Maki S. · Takakura A. · Katono K. · Sasaki J. · Sato Y. · Masuda N.
aDepartment of Respiratory Medicine, Kitasato University School of Medicine, and bDepartment of Molecular Diagnostics, School of Allied Health Sciences, Kitasato University, Sagamihara, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/17/2012 2:48:26 PM
Accepted: 8/29/2012
Published online: 11/7/2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 5

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

The purpose of this study was to evaluate the efficacy of pemetrexed monotherapy in previously treated patients with advanced non-small cell lung cancer (NSCLC) including salvage treatment, and to evaluate whether thymidylate synthase (TS) expression is a predictor for pemetrexed efficacy. Hundred and four previously treated patients with advanced NSCLC who received pemetrexed monotherapy were retrospectively evaluated for clinical efficacy and toxicity. If available, tissue specimens of patients were also analyzed immunohistochemically for TS expression. The patients’ median age was 65 years (range: 43–82). An overall response rate of 9.6% and a median progression-free survival (PFS) time of 3.4 months were achieved. The response rates for the second-line, third-line, fourth-line or further treatments were 9.1, 9.3 and 10.2% (p = 0.33); the median PFS were 3.3, 3.2 and 3.8 months (p = 0.21). The median follow-up duration was 14.9 months; the median overall survival (OS) was 11.9 months. The median PFS and OS were significantly longer in the TS-negative group than in the TS-positive group (5.8 months vs. 1.6 months; p = 0.03, and 14.7 months vs. 8.6 months; p = 0.04, respectively). Pemetrexed monotherapy could be considered as an option in the fourth or later lines of treatment of previously treated patients with advanced NSCLC as well as a second- or third-line treatment, and TS expression may be a potentially predictive factor for pemetrexed efficacy in NSCLC patients.


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/17/2012 2:48:26 PM
Accepted: 8/29/2012
Published online: 11/7/2012

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 5

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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