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Table of Contents
Vol. 74, No. 5, 2012
Issue release date: January 2013
ORL 2012;74:264–270
(DOI:10.1159/000343796)

Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma

Tan W.J. · Chia C.S. · Tan H.K. · Soo K.-C. · Iyer N.G.
aDepartment of Surgical Oncology, National Cancer Centre Singapore, and bDepartment of General Surgery, Singapore General Hospital, Singapore

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Abstract

Purpose: Staging for tongue carcinoma does not consider its depth of invasion. We aim to determine the prognostic significance of invasion depth in tongue cancer. Materials and Methods: Retrospective review of patients with tongue carcinoma who underwent curative surgery between 2002 and 2005; 67 patients were analyzed. Tumors were divided into 2 groups: group A = invasion depth <4 mm; group B = invasion depth ≥4 mm. Recurrence and survival rates were calculated for each group and compared. Results: The local recurrence rate in group B was significantly higher (10 vs. 29.7%, p = 0.048). Group A patients had a superior 5-year overall survival (68.8 vs. 41.6%, p = 0.012), disease-specific survival (67.1 vs. 41.1%, p = 0.026) and local recurrence-free survival (89.5 vs. 65.4%, p = 0.035). Five-year regional recurrence, locoregional recurrence and distant recurrence-free survival rates were not significantly different between the 2 groups (p = 0.390, p = 0.173 and p = 0.207). The impact of invasion depth on survival was maintained on multivariate analysis (p = 0.031). Conclusion: Invasion depth is an important prognostic indicator in tongue cancer.



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References

  1. Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. CA Cancer J Clin 2005;55:74–108.
  2. Pfister DG, Ang K, Briezel D: NCCN clinical practice guidelines in oncology – head and neck cancer. J Natl Compr Canc Netw 2011;9:596–650.

    External Resources

  3. Close LG, Burns DK, Reisch J, Schaefer SD: Microvascular invasion in cancer of the oral cavity and oropharynx. Arch Otolaryngol Head Neck Surg 1987;113:1191–1195.
  4. Fakih AR, Rao RS, Borges AM, Patel AR: Elective versus therapeutic neck dissection in early carcinoma of the oral tongue. Am J Surg 1989;158:309–313.
  5. Fukano H, Matsuura H, Hasegawa Y, Nakamura S: Depth of invasion as a predictive factor for cervical lymph node metastasis in tongue carcinoma. Head Neck 1997;19:205–210.
  6. Godden DR, Ribeiro NF, Hassanein K, Langton SG: Recurrent neck disease in oral cancer. J Oral Maxillofac Surg 2002;60:748–753.
  7. Jones KR, Lodge-Rigal RD, Reddick RL, Tudor GE, Shockley WW: Prognostic factors in the recurrence of stage I and II squamous cell cancer of the oral cavity. Arch Otolaryngol Head Neck Surg 1992;118:483–485.
  8. Kurokawa H, Yamashita Y, Takeda S, Zhang M, Fukuyama H, Takahashi T: Risk factors for late cervical lymph node metastases in patients with stage I or II carcinoma of the tongue. Head Neck 2002;24:731–736.
  9. O-charoenrat P, Pillai G, Patel S, Fisher C, Archer D, Eccles S, Rhys-Evans P: Tumour thickness predicts cervical nodal metastases and survival in early oral tongue cancer. Oral Oncol 2003;39:386–390.
  10. Pentenero M, Gandolfo S, Carrozzo M: Importance of tumor thickness and depth of invasion in nodal involvement and prognosis of oral squamous cell carcinoma: a review of the literature. Head Neck 2005;27:1080–1091.
  11. An SY, Jung EJ, Lee M, Kwon TK, Sung MW, Jeon YK, Kim KH: Factors related to regional recurrence in early stage squamous cell carcinoma of the oral tongue. Clin Exp Otorhinolaryngol 2008;1:166–170.
  12. Byers RM, El-Naggar AK, Lee YY, Rao B, Fornage B, Terry NH, Sample D, Hankins P, Smith TL, Wolf PJ: Can we detect or predict the presence of occult nodal metastases in patients with squamous carcinoma of the oral tongue? Head Neck 1998;20:138–144.
  13. Chen YW, Yu EH, Wu TH, Lo WL, Li WY, Kao SY: Histopathological factors affecting nodal metastasis in tongue cancer: analysis of 94 patients in Taiwan. Int J Oral Maxillofac Surg 2008;37:912–916.
  14. Larsen SR, Johansen J, Sorensen JA, Krogdahl A: The prognostic significance of histological features in oral squamous cell carcinoma. J Oral Pathol Med 2009;38:657–662.
  15. Shim SJ, Cha J, Koom WS, Kim GE, Lee CG, Choi EC, Keum KC: Clinical outcomes for T1–2N0–1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. Radiat Oncol 2010;5:43.
  16. Ganly I, Patel S, Shah J: Early stage squamous cell cancer of the oral tongue – clinicopathologic features affecting outcome. Cancer 2012;118:101–111.
  17. Lin MJ, Guiney A, Iseli CE, Buchanan M, Iseli TA: Prophylactic neck dissection in early oral tongue squamous cell carcinoma 2.1 to 4.0 mm depth. Otolaryngol Head Neck Surg 2011;144:542–548.
  18. Yuen AP, Wei WI, Wong YM, Tang KC: Elective neck dissection versus observation in the treatment of early oral tongue carcinoma. Head Neck 1997;19:583–588.


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