Pallidal Deep Brain Stimulation for a Case of Hemidystonia Secondary to a Striatal StrokeFuller J.a · Prescott I.A.b · Moro E.c · Toda H.e · Lozano A.d · Hutchison W.D.b, d
aFaculty of Medicine and bDepartment of Physiology, University of Toronto, and Divisions of cNeurology and dNeurosurgery, Toronto Western Hospital, Toronto, Ont., Canada; eDepartment of Neurosurgery, Tazuke Kofukai Medical Research Institute and Kitano Hospital, Osaka, Japan Stereotact Funct Neurosurg 2013;91:190-197 (DOI:10.1159/000345113)
Background: The efficacy of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) for medically refractory idiopathic generalized dystonia has been demonstrated repeatedly. More variable outcomes have been reported in the treatment of secondary dystonia with GPi DBS. Objectives: The present study seeks to examine the pallidal physiology and clinical outcome of GPi DBS in a case of secondary dystonia. Methods: We report on a 43-year-old man who at the age of 9 suffered a left basal ganglia stroke and at the age of 21 developed severe disabling hemidystonia. Following unsuccessful medical management for many years and an axial involvement of the dystonia, he underwent bilateral GPi DBS with dual microelectrode mapping of cell firing and evoked field potentials (fEP). Results: On the intact side we found regular firing of pallidal neurons and normal fEP indicative of functioning striatopallidal pathways. The affected side was found to include a higher frequency of bursting pallidal neurons. fEP could not be evoked on the affected side, suggesting their origin to be striatal GABAergic afferents. Conclusions: The patient had marked benefit from bilateral GPi DBS, which suggests that the therapeutic effects of DBS were mediated by the intact pathways in this case of hemidystonia.
|Direct payment||This item at the regular price: USD 38.00|
|Payment from account||With a Karger Pay-per-View account (down payment USD 150)
you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50