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Vol. 91, No. 4, 2013
Issue release date: June 2013
Section title: Clinical Study
Stereotact Funct Neurosurg 2013;91:243-247
(DOI:10.1159/000345262)

Use of Pallidal Deep Brain Stimulation in Postinfarct Hemidystonia

Witt J. · Starr P.A. · Ostrem J.L.
Departments of aNeurology and bNeurological Surgery, University of California, San Francisco and Center for Movement Disorders, San Francisco, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 2/2/2012
Accepted: 10/13/2012
Published online: 3/26/2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Background/Aims: Reports of outcomes in treating dystonia secondary to stroke with deep brain stimulation (DBS) are limited. We report our experience with 3 patients, all with infarcts involving the striatum, who developed hemidystonia and were treated with unilateral globus pallidus interna DBS. Methods: Case series describing characteristics and outcomes based on the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) scores before and after DBS at 3, 6 and at least 12 months. Results: All patients reported subjective improvements after surgery. At 1 year or more after surgery, none of the 3 patients displayed a measureable improvement in the BFMDRS movement score. Conclusion: Our findings are consistent with previous reports of limited benefits from pallidal DBS in secondary dystonia. Future work should focus on predictive factors for DBS outcomes and the development of more sensitive assessment tools specifically for secondary dystonias as well as the exploration of alternative brain targets for stimulation.


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 2/2/2012
Accepted: 10/13/2012
Published online: 3/26/2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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