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Vol. 129, No. 4, 2013
Issue release date: May 2013
Acta Haematol 2013;129:225–228

A Case Report of Acute Myeloid Leukemia after Liver Transplantation

Liu M. · Liu J. · Liu L. · Yu L. · Shi B. · Ye L. · Zhang Y. · Chen H.
aDepartment of Hematology, The 309th Hospital of Chinese People’s Liberation Army, bDepartment of Anesthesiology, The 306 Hospital of Chinese People’s Liberation Army and cDepartment of Hematology, Chinese People’s Liberation Army General Hospital, Beijing, China

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Acute myeloid leukemia (AML) is a rare complication observed after liver transplantation and only a handful of cases have been reported until now. We report a case of acute promyelocytic leukemia (APL) after liver transplantation in a 50-year-old man. The case presentation was postodontectomy bleeding with an associative abnormal coagulation test 85 months after liver transplantation. A routine blood test, bone marrow test, chromosome analysis and examination of PML/RARα chimeric gene confirmed the diagnosis of APL and disseminated intravascular coagulation (DIC). Induction chemotherapy with all-trans retinoic acid, arsenic trioxide and daunorubicin was given to this patient and complete remission was achieved. The patient was subjected to DA (daunorubicin combined with cytarabine) and MA (mitoxantrone combined with cytarabine) regimens after remission induction to consolidate the chemotherapy for two courses of treatment, and subsequently subjected to arsenous acid chemotherapy on a periodic basis. Twenty-two months into the follow-up, sustained bone marrow remission was observed with the adapted treatment regimen.

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