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Vol. 34, No. 5-6, 2012
Issue release date: January 2013
Dement Geriatr Cogn Disord 2012;34:307–311

Analysis of Neuron-Specific Enolase and S100B as Biomarkers of Cognitive Decline Following Surgery in Older People

Jones E.L. · Gauge N. · Nilsen O.B. · Lowery D. · Wesnes K. · Katsaiti E. · Arden J. · Amoako D. · Prophet N. · Purushothaman B. · Green D. · Ballard C.
aWolfson Centre for Age-Related Disease, King’s College London, Guy’s Campus, bDepartment of Anaesthetics, King’s College Hospital, and cResearch Department of Primary Care and Population Health, University College London, London, UK; dFaculty of Science and Technology, Stavanger University Hospital, Stavanger, Norway; eCentre for Human Psychopharmacology, Swinburne University, Melbourne, Australia

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Background/Aims: Post-operative cognitive decline is frequent in older individuals following major surgery; however, biomarkers of this decline are less clearly defined. Methods: Sixty-eight participants over the age of 60 provided blood samples at baseline and 24 h post-surgery. Cognitive decline was measured at baseline and 52 weeks post-surgery using the Cambridge Assessment for Mental Disorder in the Elderly, section B (CAMCOG) score. Plasma levels of neuron-specific enolase (NSE) and S100B were measured by ELISA. Results: Baseline NSE and the change in NSE levels between baseline and 24 h were correlated with the change in CAMCOG score between baseline and 52 weeks. Conclusion: NSE concentrations may be a useful predictor of individuals at risk of more severe long-term cognitive decline.

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