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Vol. 75, No. 2, 2013
Issue release date: February 2013
Section title: Novel Insights from Clinical Practice
Gynecol Obstet Invest 2013;75:139-144
(DOI:10.1159/000345863)

Two Cases of Malignant Struma Ovarii with Metastasis to Pelvic Bone

Steinman R.A. · De Castro I.O. · Shrayyef M. · Chengazi V. · Giampoli E. · Van Der Sloot P. · Calvi L.M. · Wittlin S.D. · Hammes S.R. · Hou R.
aDivision of Endocrinology and Metabolism, Departments of bRadiology, and cPathology, dDivision of Otolaryngology, University of Rochester School of Medicine, Rochester, N.Y., USA; eDepartment of Medicine, Moncton Hospital, Moncton, N.B., fDepartment of Medicine, Dalhousie University, Halifax, N.S., and gDepartment of Medicine, Memorial University, St. John, Nfld., Canada

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Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 1/9/2012 2:19:09 PM
Accepted: 11/14/2012
Published online: 2/5/2013

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI

Abstract

Histologically, malignant struma ovarii metastasizes rarely, and only a few cases reported bone metastasis. Here, we describe 2 cases of biologically malignant struma ovarii with pelvic bone metastasis. Case 1 is a 22-year-old female who was found to have a large left ovarian mass during routine prenatal ultrasound. Papillary thyroid cancer arising in struma ovarii was identified after laparoscopic salpingo-oophorectomy. After total thyroidectomy, radioactive iodine whole-body scan revealed extrathyroidal iodine uptake in left anterior pelvis. Subsequent I-131 treatment resolved the pelvic metastasis. Case 2 is a 49-year-old female who was diagnosed with malignant struma ovarii in 1996 and presented in 2007 with pelvic recurrence and extensive left hip metastasis. Treatment with resection of the pelvic tumor, total thyroidectomy, and multiple I-131 ablation led to eventual resolution of the abdominal and left hip foci. In conclusion, we present 2 rare cases of malignant struma ovarii, both with metastasis to the pelvic bone. This report makes pelvic bone the most frequent site for bone metastasis in malignant struma ovarii. It also emphasizes the importance of total thyroidectomy in allowing identification and treatment of bony metastasis with radioactive iodine.


Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: 1/9/2012 2:19:09 PM
Accepted: 11/14/2012
Published online: 2/5/2013

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 0

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

For additional information: http://www.karger.com/GOI


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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