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Vol. 91, No. 1-2, 2013
Issue release date: February 2013
Section title: Short Communication
Pharmacology 2013;91:112–116
(DOI:10.1159/000345929)

Pharmacokinetic Interaction between Losartan and Rhodiola rosea in Rabbits

Spanakis M. · Vizirianakis I.S. · Batzias G. · Niopas I.
aDepartment of Pharmacognosy and Pharmacology, School of Pharmacy and bLaboratory of Veterinary Pharmacology, School of Veterinary Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 11/8/2012 11:26:34 AM
Accepted: 11/15/2012 4:29:04 PM
Published online: 1/17/2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA

Abstract

Aim: The study investigates the potential interaction of the herbal medicinal product of Rhodiola rosea on the pharmacokinetics of losartan and its active metabolite EXP3174 after concurrent oral administration to rabbits. Materials and Methods: We conducted a randomized, single-dose, two-treatment, two-period, two-sequence, cross-over pharmacokinetic study on 6 healthy female New Zealand rabbits, after concurrent oral administration of losartan (5 mg/kg) and the herbal medicinal product of R. rosea (50 mg/kg). Quantification of losartan and its main active metabolite EXP3174 was achieved using a validated HPCL/UV method. Pharmacokinetic and statistical analysis was performed using the EquivTest/PK software. Observations: Administration of the herbal medicinal product of R. rosea resulted in a statistically significant increase of the following pharmacokinetic parameters for losartan: the maximum plasma concentration (Cmax), the area under the curve (AUC) and the apparent total body clearance (CL/F). An almost 2-fold increase in the AUC of losartan was observed after concurrent administration of the herbal medicinal product of R. rosea. No statistically significant alteration was observed in the pharmacokinetic parameters of the active metabolite of losartan EXP3174. Conclusion: The data of this study suggest that R. rosea significantly alters the pharmacokinetic properties of losartan after concurrent oral administration to rabbits. A study in humans should be conducted to assess the clinical significance of a possible herb-drug interaction between the herbal medicinal products of R. rosea and drugs such as losartan, which are substrates of both CYPs and P-gp.


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Received: 11/8/2012 11:26:34 AM
Accepted: 11/15/2012 4:29:04 PM
Published online: 1/17/2013

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 0031-7012 (Print)
eISSN: 1423-0313 (Online)

For additional information: http://www.karger.com/PHA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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