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Vol. 67, No. 3, 2013
Issue release date: April 2013
Section title: Case Report
Neuropsychobiology 2013;67:181-184
(DOI:10.1159/000346654)

EMDR Therapy Modulates the Default Mode Network in a Subsyndromal, Traumatized Bipolar Patient

Landin-Romero R. · Novo P. · Vicens V. · McKenna P.J. · Santed A. · Pomarol-Clotet E. · Salgado-Pineda P. · Shapiro F. · Amann B.L.
aFIDMAG Research Foundation Germanes Hospitalàries, bCIBERSAM, cDepartament de Psiquiatria i Medicina Legal, Doctorat de Psiquiatria i Psicología Clínica, Universitat Autònoma de Barcelona, dCentro Adala de Atencion Psicologica, Barcelona, Spain; eMental Research Institute, Palo Alto, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 8/7/2012 5:08:16 PM
Accepted: 12/14/2012
Published online: 3/16/2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Background: Some functional imaging abnormalities found in bipolar disorder are state related, whereas others persist into euthymia. It is uncertain to what extent these latter changes may reflect continuing subsyndromal affective fluctuations and whether those can be modulated by therapeutic interventions. Method: We report functional magnetic resonance imaging (fMRI) findings during performance of the n-back working memory task in a bipolar patient who showed a marked improvement in subsyndromal affective symptoms after receiving eye movement desensitization and reprocessing (EMDR) therapy in the context of a clinical trial. Results: The patient's clinical improvement was accompanied by marked changes in functional imaging, as compared to 30 healthy subjects. fMRI changes were noted particularly in deactivation, with failure of deactivation in the medial frontal cortex partially normalizing after treatment. Conclusions: This case supports the potential therapeutic overall benefit of EMDR in traumatized bipolar patients and suggests a possible neurobiological mechanism of action: normalization of default mode network dysfunction.


Article / Publication Details

First-Page Preview
Abstract of Case Report

Received: 8/7/2012 5:08:16 PM
Accepted: 12/14/2012
Published online: 3/16/2013

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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