Cover

Toothpastes

Editor(s): van Loveren C. (Amsterdam) 
Table of Contents
Vol. 23, 2013
Section title:  
van Loveren C (ed): Toothpastes. Monogr Oral Sci. Basel, Karger, 2013, vol 23, pp 27-44
(DOI:10.1159/000350465)

Antiplaque and Antigingivitis Toothpastes

Sanz M. · Serrano J. · Iniesta M. · Santa Cruz I. · Herrera D.
Etiology and Therapy of Periodontal Diseases Research Group, Faculty of Odontology, University Complutense, Madrid, Spain

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Article / Publication Details

First-Page Preview
Abstract of  

Published online: 6/28/2013
Cover Date: 2013

Number of Print Pages: 18
Number of Figures: 1
Number of Tables: 3

ISBN: 978-3-318-02206-3 (Print)
eISBN: 978-3-318-02207-0 (Online)

Abstract

Dentifrices are a general term used to describe preparations that are used together with a toothbrush with the purpose to clean and/or polish the teeth. Active toothpastes were first formulated in the 1950s and included ingredients such as urea, enzymes, ammonium phosphate, sodium lauryl sarcosinate and stannous fluoride. Later, therapeutic agents were included. Today's toothpastes have two objectives: to help the toothbrush in cleaning the tooth surface and to provide a therapeutic effect. The therapeutic effect may have an antiplaque or anti-inflammatory basis when the nature of the agents is antimicrobial. Plaque inhibitory and antiplaque activity of toothpastes used for chemical plaque control is evaluated in distinct consecutive stages, the last being home use randomized clinical trials of at least 6 months' duration. In this chapter, the scientific evidence supporting the use of the most common antiplaque agents, included in toothpaste formulations, is reviewed, with a special emphasis on 6-month clinical trials, and systematic reviews with meta-analyses of the mentioned studies. Among the active agents, the following have been included in toothpastes: enzymes, amine alcohols, herbal or natural products, triclosan, bisbiguanides (chlorhexidine), quaternary ammonium compounds (cetylpyridinium chloride) and different metal salts (zinc salts, stannous fluoride, stannous fluoride with amine fluoride). Dentifrices are the ideal vehicles for any active ingredient used as an oral health preventive measure since they are used in combination with toothbrushing, which is the most frequently employed oral hygiene method. The most important indications of dentifrices with active ingredients are associated with long-term use to prevent bacterial biofilm formation, mostly in gingivitis patients or in patients on supportive periodontal therapy.


Article / Publication Details

First-Page Preview
Abstract of  

Published online: 6/28/2013
Cover Date: 2013

Number of Print Pages: 18
Number of Figures: 1
Number of Tables: 3

ISBN: 978-3-318-02206-3 (Print)
eISBN: 978-3-318-02207-0 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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