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Vol. 130, No. 4, 2013
Issue release date: November 2013

Acute Hemolytic Anemia in Glucose-6-Phosphate Dehydrogenase Deficiency Complicated by Ginkgo biloba

Lai S.-W. · Chen J.-H. · Kao W.-Y.
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Abstract

We report on a patient with glucose-6-phosphate dehydrogenase (G6PD) deficiency who developed acute hemolytic anemia after having received an injection of Ginkgo biloba for dementia prophylaxis without medical advice. She suddenly developed general malaise, generalized yellowish skin color, and tea-colored urine. Intravenous fluid infusion and cessation of G. biloba quickly relieved her clinical symptoms. To the best of our knowledge, this is the first case report of G. biloba-induced acute hemolytic anemia in vivo. © 2013 S. Karger AG, Basel



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References

  1. Bent S, Goldberg H, Padula A, Avins AL: Spontaneous bleeding associated with Ginkgo biloba: a case report and systematic review of the literature. J Gen Intern Med 2005;20:657-661.
  2. Rotblatt M, Ziment I: Evidence-Based Herbal Medicine. Philadelphia, Hanley & Belfus, 2002.
  3. Pawlikowska-Pawlega B, Gruszecki WI, Misiak LE, Gawron A: The study of the quercetin action on human erythrocyte membranes. Biochem Pharmacol 2003;66:605-612.
  4. Robaszkiewicz A, Balcerczyk A, Bartosz G: Antioxidative and prooxidative effects of quercetin on A549 cells. Cell Biol Int 2007;31:1245-1250.
  5. Shao ZH, Vanden Hoek TL, Xie J, Wojcik K, Chan KC, Li CQ, Hamann K, Qin Y, Schumacker PT, Becker LB, Yuan CS: Grape seed proanthocyanidins induce pro-oxidant toxicity in cardiomyocytes. Cardiovasc Toxicol 2003;3:331-339.
  6. Galati G, Sabzevari O, Wilson JX, O'Brien PJ: Prooxidant activity and cellular effects of the phenoxyl radicals of dietary flavonoids and other polyphenolics. Toxicology 2002;177:91-104.
  7. He J, Lin J, Li J, Zhang JH, Sun XM, Zeng CM: Dual effects of Ginkgo biloba leaf extract on human red blood cells. Basic Clin Pharmacol Toxicol 2009;104:138-144.
  8. Kessler M, Ubeaud G, Jung L: Anti- and pro-oxidant activity of rutin and quercetin derivatives. J Pharm Pharmacol 2003;55:131-142.
  9. Sahu SC, Gray GC: Pro-oxidant activity of flavonoids: effects on glutathione and glutathione S-transferase in isolated rat liver nuclei. Cancer Lett 1996;104:193-196.
  10. Laughton MJ, Halliwell B, Evans PJ, Hoult JR: Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Effects on lipid peroxidation, hydroxyl radical generation and bleomycin-dependent damage to DNA. Biochem Pharmacol 1989;38:2859-2865.
  11. Yen GC, Duh PD, Tsai HL, Huang SL: Pro-oxidative properties of flavonoids in human lymphocytes. Biosci Biotechnol Biochem 2003;67:1215-1222.
  12. Cappellini MD, Fiorelli G: Glucose-6-phosphate dehydrogenase deficiency. Lancet 2008;371:64-74.
  13. Youngster I, Arcavi L, Schechmaster R, Akayzen Y, Popliski H, Shimonov J, Beig S, Berkovitch M: Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review. Drug Saf 2010;33:713-726.
  14. Nang Kuang Pharmaceutical Co., Ltd. http://nangkuang1963.en.gongchang.com (accessed July 28, 2012).


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