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Vol. 226, No. 4, 2013
Issue release date: September 2013
Section title: Original Paper
Dermatology 2013;226:347-352
(DOI:10.1159/000350939)

Cutaneous Adverse Drug Reaction to Oral Acetazolamide and Skin Tests

Jachiet M. · Bellon N. · Assier H. · Amsler E. · Gaouar H. · Pecquet C. · Bourrain J.L. · Bégon E. · Chosidow O. · Francès C. · Ingen-Housz-Oro S. · Soria A.
aDepartment of Dermatology and Allergology, AP-HP, Hôpital Tenon, Paris, bDepartment of Dermatology, AP-HP, Hôpital Henri Mondor, Créteil, cDepartment of Dermatology, Hôpital A. Michallon, Grenoble, dDepartment of Dermatology, Hôpital René Dubos, Pontoise, and eUniversité Paris-Est Créteil Val de Marne, Créteil, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/21/2013 8:27:28 AM
Accepted: 3/18/2013
Published online: 6/29/2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Few cases of cutaneous adverse drug reactions (CADR) to oral acetazolamide, a non-antimicrobial sulfonamide, have been previously reported, and the interest of acetazolamide skin tests has never been studied. Objectives: We report a series of ten patients with oral acetazolamide CADR and skin tests. Patients and Methods: The files of ten patients with CADR secondary to oral acetazolamide prescribed for cataract surgery in most cases referred between 2001 and 2011 in four French dermatology and allergy departments were retrospectively reviewed. Skin tests with acetazolamide were performed in nine patients and twelve controls. Other sulfonamides were tested in five of ten patients. Results: Seven patients developed maculopapular exanthema and four had acute generalized exanthematous pustulosis. Patch tests were positive for 8/9 patients, prick tests for 2/4 and intradermal tests for 3/3. Patch and prick or intradermal test results were concordant in 2/3 positive subjects. Patch tests for other sulfonamides were negative, as were patch tests in controls. Conclusions: We report the largest series of CADR to oral acetazolamide (maculopapular exanthema or acute generalized exanthematous pustulosis). A drug eruption after cataract surgery should be investigated for accountability of acetazolamide. In view of this retrospective study, skin tests and particularly intradermal tests appear to be an important contribution to demonstrate accountability.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/21/2013 8:27:28 AM
Accepted: 3/18/2013
Published online: 6/29/2013

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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