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Vol. 104, No. 4, 2013
Issue release date: November 2013
Section title: Original Paper
Neonatology 2013;104:298-304
(DOI:10.1159/000351020)

Risk Factors and Correlates of Neonatal Growth Velocity in Extremely Low Gestational Age Newborns. The ELGAN Study

Bartholomew J. · Martin C.R. · Allred E. · Chen M.L. · Ehrenkranz R.A. · Dammann O. · Leviton A.
aDivision of Newborn Medicine, Floating Hospital for Children at Tufts Medical Center, bDepartment of Neonatology Beth Israel Deaconess Medical Center, cNeuroepidemiology Unit, Children's Hospital, dDepartment of Public Health and Community Medicine, Tufts University School of Medicine, Boston, Mass., and eDivision of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, Conn., USA; fPerinatal Neuroepidemiology Unit, Hannover Medical School, Hannover, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/14/2012 9:41:07 AM
Accepted: 3/18/2013
Published online: 10/30/2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 6

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Objectives: To identify maternal and infant characteristics associated with reduced growth velocity (GV) in extremely premature newborns. Methods: We evaluated 1,187 infants born between 23 and 27 weeks' gestation at 14 institutions between 2002 and 2004 who survived until day 28 to identify the maternal and infant characteristics associated with a GV and caloric intake in the lowest quartile. Results: Newborns in the lowest gestational age and low birth weight categories, as well as those with intrauterine growth restriction, or high SNAP-II received relatively fewer kcal/kg/day than their peers without these risk factors, but were not at increased risk of being in the lowest GV quartile. Newborns with bacteremia, patent ductus arteriosus, retinopathy of prematurity stage 3-5, or pulmonary illness received fewer calories, as did those who received medications or blood transfusions. However, in a multivariable model adjusting for confounders, only ventilator dependence on day 7 (OR 2.2, 95% CI 1.5-3.2), early persistent pulmonary dysfunction (OR 1.8, 95% CI 1.3-2.5), and postnatal exposure to dexamethasone (OR 2.8, 95% CI 1.2-6.5) were associated with an increased risk of being in the lowest GV quartile. In this model, low caloric intake was not associated with low GV (OR 1.3, 95% CI 0.9-1.9). Conclusion: Variables associated with severe pulmonary disease convey more information about the risk of reduced GV during the first 28 postnatal days than does low caloric intake.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/14/2012 9:41:07 AM
Accepted: 3/18/2013
Published online: 10/30/2013

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 6

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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