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Association between EEG Abnormalities and CSF Biomarkers in a Memory Clinic Cohort

Kramberger M.G.a,b,i · Kåreholt I.c,e,h · Andersson T.f · Winblad B.a, b · Eriksdotter M.a,b,d,g · Jelic V.a,b,d,g
aDepartment of Neurobiology, Care Sciences and Society, bAlzheimer Research Centre, cAging Research Centre, and dDepartment of NVS, Karolinska Institutet, eStockholm University, and Departments of fClinical Neurophysiology and gGeriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, and hInstitute for Gerontology, School of Health Sciences, Jönköping University, Jönköping, Sweden; iDepartment of Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia Dement Geriatr Cogn Disord 2013;36:319-328 (DOI:10.1159/000351677)


Background: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers. Methods: Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). Results: BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). Conclusions: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration. © 2013 S. Karger AG, Basel


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