A Computerized Asthma-Specific Quality of Life: A Novel Tool for Reflecting Asthma Control and Predicting ExacerbationKim M.-A. · Ye Y.-M. · Park J.-W. · Lee J.-H. · Lee S.-K. · Kim C.-W. · Jung K.-S. · Kim J.-H. · Yoo H.-S. · Kim S.-H. · Shin Y.S. · Nahm D.-H. · Park H.-S. · on behalf of the Premier Researchers Aiming New Era in Asthma and Allergic Diseases (PRANA) Study Group
aDepartment of Allergy and Clinical Immunology, Ajou University School of Medicine, Suwon, bDepartment of Internal Medicine and Institute of Allergy, Yonsei University College of Medicine, Seoul, cDepartment of Internal Medicine, Dong-A University College of Medicine, Busan, dDepartment of Internal Medicine, Inha University College of Medicine, Incheon, eDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University Medical School, Pyeongchon, Republic of Korea
Background: Proper assessment of health-related quality of life is essential to achieve and maintain a controlled status in asthmatic patients. We developed our own computerized asthma-specific quality-of-life (cA-QOL) questionnaire based on in-depth interviews with adult asthmatic patients. In this study, we evaluated this cA-QOL in terms of the Asthma Control Test (ACT) score and Global Initiative for Asthma (GINA) guidelines as well as asthma exacerbation, and compared it with the asthma-related quality-of-life questionnaire (AQLQ). Methods: We conducted a multicenter, prospective, observational study in 133 adult asthmatic patients recruited from 5 university hospitals in South Korea, who were randomized into 2 groups according to the operating order of the cA-QOL and AQLQ. At every visit (3-month interval), physicians evaluated asthma control status with monitoring spirometry. The self-administered cA-QOL, AQLQ(S) and ACT were completed. Results: The cA-QOL scores correlated significantly with ACT and AQLQ(S) scores (r = 0.814, p < 0.001; r = 0.900, p < 0.001). The cA-QOL score was significantly lower where the ACT score was <19, in the patients with an uncontrolled asthma status according to the GINA guidelines and in those with asthma exacerbation (p < 0.001, respectively). A multivariate analysis showed that this cA-QOL was a significant parameter associated with an uncontrolled asthma status and asthma exacerbation (p < 0.001, p = 0.045, p = 0.019, respectively). Conclusion: The cA-QOL is a valid tool for reflecting current asthma control status and for assessment to predict the future risk of asthma exacerbation in adult asthmatics.