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Vol. 21, No. 5, 2014
Issue release date: June 2014
Neuroimmunomodulation 2014;21:250-256
(DOI:10.1159/000357309)

Evaluation of Neuroimmunomodulatory Activity of Recombinant Human Interferon α

Mehta S. · Mukherjee S. · Balasubramanian D. · Chowdhary A.
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Abstract

Objective: Recombinant human interferon (rhIFN)-α is a potent immunoregulator having a wide range of therapeutic applications. In the present study, rhIFN-α was evaluated for its neuroimmunomodulatory activity. Method: Dose-dependent gene expression of cytokines and chemokines in the brain of rhIFN-administered mice was studied using real-time SYBR green PCR. Results: Statistically significant increase in expression levels of tumor necrosis factor-α, interleukin (IL)-6, IL-1β and IFN-γ were observed. Conclusion: The findings indicate that rhIFN-α may be used at an optimized dose to cause appropriate neuromodulation of cytokine/chemokine secretion that can aid in the development of therapeutic approaches for many infectious diseases of the central nervous system for which therapies are lacking. © 2014 S. Karger AG, Basel



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