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Effect of Ozone on Red Blood Cell Enzymes and Intermediates

Zimran A.a · Wasser G.b · Forman L.c · Gelbart T.c · Beutler E.c
aDepartment of Medicine, Shaare-Zedek Medical Center, Jerusalem, Israel; bInstitute of Environmental Medicine, Erfurt, Germany; cDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif., USA Acta Haematol 1999;102:148–151 (DOI:10.1159/000040990)


Ozone autohemotherapy has been considered a form of alternative medicine and has not yet been subjected to the rigors of well-designed clinical trials. Despite encouraging anecdotal reports regarding the use of ozone in various disorders, there has been a concern that ozone per se may adversely affect red cell membranes and metabolites. The purpose of this study was to ascertain the effect of ozone administration at a concentration commonly used in autohemotherapy on a panel of red cell enzymes and intermediates, as well as its effect on red cell integrity. Since these parameters were unaffected by ozone, we suggest that clinical trials for the use of ozone autohemotherapy should be encouraged.

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