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Vol. 102, No. 3, 1999
Issue release date: January 2000
Acta Haematol 1999;102:148–151
(DOI:10.1159/000040990)

Effect of Ozone on Red Blood Cell Enzymes and Intermediates

Zimran A. · Wasser G. · Forman L. · Gelbart T. · Beutler E.
aDepartment of Medicine, Shaare-Zedek Medical Center, Jerusalem, Israel; bInstitute of Environmental Medicine, Erfurt, Germany; cDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif., USA

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Abstract

Ozone autohemotherapy has been considered a form of alternative medicine and has not yet been subjected to the rigors of well-designed clinical trials. Despite encouraging anecdotal reports regarding the use of ozone in various disorders, there has been a concern that ozone per se may adversely affect red cell membranes and metabolites. The purpose of this study was to ascertain the effect of ozone administration at a concentration commonly used in autohemotherapy on a panel of red cell enzymes and intermediates, as well as its effect on red cell integrity. Since these parameters were unaffected by ozone, we suggest that clinical trials for the use of ozone autohemotherapy should be encouraged.

Copyright © 2000 S. Karger AG, Basel



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References

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    External Resources

  2. Bocci V: Autohemotherapy after treatment of blood with ozone. A reappraisal. J Int Med Res 1993;22:131–144.
  3. Beck EG, Viebahn-Hansler J: Ozone Handbook. Grundwerk Publications, 1995.
  4. Beutler E: Red Cell Metabolism: A Manual of Biochemical Methods. New York, Grune & Stratton, 1984.
  5. Jonas WB: Alternative medicine – learning from the past, examining the present, advancing to the future. JAMA 1998;280:1616–1617.
  6. Beutler E, West C: Storage of red cell concentrates in CPD-A2 for 42 and 49 days. J Lab Clin Med 1983;102:53–62.

    External Resources

  7. Zeller WP, Eyzaguirre M, Hannigan J, Ozog K, Suarez C, Silberman S, Hoffstadter A, Hurley RM: Fast hemoglobins and red blood cell metabolites in citrate phosphate dextrose adenine stored blood. Ann Clin Lab Sci 1985;15:61–65.

    External Resources

  8. Hart H: Organic Chemistry – A Short Course, ed 7. Boston, Houghton Mifflin, 1987.


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