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Table of Contents
Vol. 81, No. 3, 1999
Issue release date: March 1999
Section title: Original Paper
Nephron 1999;81:296–300
(DOI:10.1159/000045296)

Renal Function in Cyanotic Congenital Heart Disease

Burlet A. · Drukker A. · Guignard J.-P.
Division of Nephrology, Department of Pediatrics, University Medical Centre, Lausanne, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/26/1999

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF

Abstract

We performed renal function tests in 18 young patients, 1.8–14.6 years of age, with cyanotic congenital heart disease (CCHD). Glomerular filtration rate was normal (116 ± 4.5 ml/min/1.73 m2), and renal plasma flow was decreased (410 ± 25 ml/min/1.73 m2) with a rise in the filtration fraction (29 ± 1.1%). The suggested pathophysiologic explanation of these findings is that the blood hyperviscosity seen in patients with CCHD causes an overall increase in renal vascular resistance with a rise in intraglomerular blood pressure. Despite a sluggish flow of blood in the glomerular capillary bed, the effective filtration pressure was adjusted to conserve the glomerular filtration rate. In addition to these renal hemodynamic parameters, we also studied renal acidification and tubular sodium and water handling during a forced water diuresis. Our data indicate that children with CCHD have a mild to moderate normal ion gap metabolic acidosis due to a low proximal tubular threshold for bicarbonate. Proximal tubular sodium and water reabsorption under these conditions were somewhat increased, though not significantly, probably due to intrarenal hydrostatic forces, in particular the rise in the oncotic pressure in the postglomerular capillaries in patients with high hematocrit values. The distal tubular functions such as sodium handling and acidification were not affected.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 2/26/1999

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 2

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

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