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Table of Contents
Vol. 81, No. 3, 1999
Issue release date: March 1999
Section title: Letter to the Editor
Nephron 1999;81:347–348
(DOI:10.1159/000045304)

Debrisoquine 4-Hydroxylation and the Balkan Endemic Nephropathy

Mantle P.G. · Amirtharajah M. · Klippel S. · Miljkovic A. · Naik J.T. · Nestler S.
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK

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Article / Publication Details

Published online: 2/26/1999

Number of Print Pages: 2
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


First-Page Preview
Abstract of Letter to the Editor

Article / Publication Details

Published online: 2/26/1999

Number of Print Pages: 2
Number of Figures: 1
Number of Tables: 0

ISSN: 1660-8151 (Print)
eISSN: 2235-3186 (Online)

For additional information: http://www.karger.com/NEF


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Cvoriscec D, Ceovic S, Stavljenic-Rukavina A (eds): Endemic nephropathy in Croatia. Academia Croatica scientiarum medicarum 1996;XIV:100.
  2. Nikolov IG, Chernozemsky IN, Idle JR: Genetic predisposition to Balkan endemic nephropathy: Ability to hydroxylate debrisoquine as a host risk factor; in Castegnaro M, et al (eds): Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Lyon, International Agency for Research on Cancer, 1991, Publ 115, pp 289–296.
  3. Gonzalez FJ: The CYP2D subfamily; in Ioannides C (ed): Cytochromes P450: Metabolic and Toxicological Aspects. Boca Raton, CRC Press, 1996, pp 183–210.
  4. Mantle PG, McHugh KM: Nephrotoxic fungi in foods from nephropathy households in Bulgaria. Mycol Res 1993;97:205–212.
  5. Duche JC, Barre J, Tillement JP: Rapid liquid chromatographic determination of debrisoquine and its hydroxy metabolite in human urine to define hydroxylation phenotypes. J Chromatogr 1987;423:340–343.

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