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Vol. 81, No. 3, 1999
Issue release date: March 1999
Nephron 1999;81:347–348

Debrisoquine 4-Hydroxylation and the Balkan Endemic Nephropathy

Mantle P.G. · Amirtharajah M. · Klippel S. · Miljkovic A. · Naik J.T. · Nestler S.
Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, UK

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Abstract of Letter to the Editor

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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  1. Cvoriscec D, Ceovic S, Stavljenic-Rukavina A (eds): Endemic nephropathy in Croatia. Academia Croatica scientiarum medicarum 1996;XIV:100.
  2. Nikolov IG, Chernozemsky IN, Idle JR: Genetic predisposition to Balkan endemic nephropathy: Ability to hydroxylate debrisoquine as a host risk factor; in Castegnaro M, et al (eds): Mycotoxins, Endemic Nephropathy and Urinary Tract Tumours. Lyon, International Agency for Research on Cancer, 1991, Publ 115, pp 289–296.
  3. Gonzalez FJ: The CYP2D subfamily; in Ioannides C (ed): Cytochromes P450: Metabolic and Toxicological Aspects. Boca Raton, CRC Press, 1996, pp 183–210.
  4. Mantle PG, McHugh KM: Nephrotoxic fungi in foods from nephropathy households in Bulgaria. Mycol Res 1993;97:205–212.
  5. Duche JC, Barre J, Tillement JP: Rapid liquid chromatographic determination of debrisoquine and its hydroxy metabolite in human urine to define hydroxylation phenotypes. J Chromatogr 1987;423:340–343.

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