Journal Mobile Options
Table of Contents
Vol. 86, No. 3, 2000
Issue release date: November 2000

Molecular Biology of Transplantation

Krensky A.M.
To view the fulltext, log in and/or choose pay-per-view option

Individual Users: Register with Karger Login Information

Please create your User ID & Password





Contact Information











I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Abstract

The past decade has witnessed an explosion in our understanding of the molecules involved in transplant rejection and acceptance. This review highlights our current understanding of antigen recognition, signal transduction, and effector mechanisms of the immune system. Such information has proven important in understanding the action of immunosuppressive drugs and will prove useful in the design of new immunotherapies.



Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Krensky AM: The HLA system, antigen processing and presentation. Kidney Int 1997;51:S2–S7.
  2. Krensky AM, Weiss A, Crabtree G, Davis M, Parham P: Mechanisms of disease: T lymphocyte-antigen interactions in transplant rejection. N Engl J Med 1990;322:510–517.

    External Resources

  3. Parnes JR: Molecular biology and function of CD4 and CD8. Adv Immunol 1989;44:265–312.
  4. McMurray RW: Adhesion molecules in autoimmune disease. Semin Arthritis Rheum 1996;25:215–233.
  5. Sayegh MH, Turka LA: The role of T cell costimulatory activation in transplant rejection. N Engl J Med 1998;338:1813–1821.
  6. Fallarino F, Fields PE, Gajewski TF: B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J Exp Med 1998;188:205–210.
  7. Grewal IS, Flavell RA: CD40 and CD154 in cell-mediated immunity. Annu Rev Immunol 1998;16:111–135.
  8. Ramesh N, Morio T, Fuleihan R, Worm M, Horner A, Tsitsikov E, Castigli E, Geha RS: CD40-CD40 ligand (CD40L) interactions and X-linked hyperIgM syndrome (HIGMX-1). Clin Immunol Immunopathol 1995;76:S208–S213.

    External Resources

  9. Van Gool SW, Vandenberghe P, de Boer M, Ceuppens JL: CD80, CD86 and CD40 provide accessory signals in a multiple-step T-cell activation model. Immunol Rev 1996;153:47–83.

    External Resources

  10. Cantrell D: T cell antigen receptor signal transduction pathways. Annu Rev Immunol 1996;14:259–274.
  11. Rao A, Luo C, Hogan PG: Transcription factors of the NFAT family: Regulation and function. Annu Rev Immunol 1997;15:707–747.
  12. Ruhlmann A, Nordheim A: Effects of the immunosuppressive drugs CsA and FK-506 on intracellular signalling and gene regulation. Immunobiology 1997;198:192–206.
  13. Butcher EC, Picker LJ: Lymphocyte homing and homeostasis. Science 1996;272:60–66.
  14. Springer TA: Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 1994;76:301–314.
  15. Heemann UW, Schmid C, Azuma H, Tilney NL: The role of leukocyte adhesion molecules in acute transplant rejection. Curr Opin Nephrol Hypertens 1994;3:459–464.
  16. Nelson PJ, Krensky AM: Chemokines, lymphocytes, and viruses: What goes around, comes around. Curr Opin Immunol 1998;10:265–270.

    External Resources

  17. Xia M, Leppert D, Hauser SL, Sreedharan SP, Nelson P, Krensky AM, Goetzl EJ: Stimulus specificity of matrix metalloproteinase dependence of human T cell migration through a model basement membrane. J Immunol 1996;156:160–167.

    External Resources

  18. Risau W: Differentiation of endothelium. FASEB J 1995;9:926–933.
  19. Tanio JW, Basu CB, Albelda SM, Eisen HJ: Differential expression of the cell adhesion molecules ICAM-1, VCAM-1, and E-selectin in normal and posttransplantation myocardium. Cell adhesion molecule expression in human cardiac allografts. Circulation 1994;89:1760–1768.
  20. Gaston RS: Cytokines and transplantation: A clinical perspective. Transplant Sci 1994;4(suppl 1):9–19.

    External Resources

  21. Carter LL, Dutton RW: Type 1 and type 2: A fundamental dichotomy for all T-cell subsets. Curr Opin Immunol 1996;8:336–342.

    External Resources

  22. Atkinson EA, Bleackley RC: Mechanisms of lysis by cytotoxic T cells. Crit Rev Immunol 1995;15:359–384.

    External Resources

  23. Pena SV, Krensky AM: Granulysin, a new human cytolytic granule-associated protein with possible involvement in cell-mediated cytotoxicity. Semin Immunol 1997;9:117–125.
  24. Depraetere V, Golstein P: Fas and other cell death signaling pathways. Semin Immunol 1997;9:93–107.

    External Resources

  25. Krensky AM, Clayberger C: Prospects for induction of tolerance in renal transplantation. Pediatr Nephrol 1994;8:772–779.
  26. Lewis DB: Cellular immunity of the human fetus and neonate. Immunol Allergol Clin North Am 1998;18:291–328.
  27. Krensky AM: Immune response to allografts; in Moran DJ, Suki WN (eds): Primer on Transplantation. Thorofare/NJ, American Society to Transplantation, 1998.


Pay-per-View Options
Direct payment This item at the regular price: USD 38.00
Payment from account With a Karger Pay-per-View account (down payment USD 150) you profit from a special rate for this and other single items.
This item at the discounted price: USD 26.50