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Table of Contents
Vol. 106, No. 1-2, 2001
Issue release date: September 2001
Section title: Paper
Acta Haematol 2001;106:25–32
(DOI:10.1159/000046586)

Update on Tumor Cell Procoagulant Factors

Gale A.J. · Gordon S.G.
aDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, Calif., and bDepartment of Biology, San Diego State University, San Diego, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/12/2001

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Tumor cells produce tissue factor, cancer procoagulant, plasminogen activators and other factors that interact with the coagulation system, the fibrinolytic system and vascular or blood cells such that they can upset the normal homeostasis and balance between activation and inhibition of the coagulation and fibrinolytic systems. These activities play a role in tumor cell growth and metastasis, vascular wall function, and hemostasis. Proteases and their inhibitors are intimately involved in all aspects of the hemostatic, cell proliferation and cellular signalling systems. This review provides a brief examination of recent observations in this complex interaction of cellular and hemostatic factors.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 9/12/2001

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 0

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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