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Vol. 44, No. 5-6, 2000
Issue release date: September–December 2000

Influence of Highly Active Antiretroviral Therapy on Micronutrient Profiles in HIV-Infected Patients

Rousseau M.C. · Molines C. · Moreau J. · Delmont J.
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Objectives: To assess micronutrient variations in HIV/AIDS patients before and after HAART (highly active antiretroviral therapy). Methods: We evaluated the nutritional status and micronutrients in 44 patients over 3 years. The first nutritional evaluation was conducted in 1995 before HAART, the second was conducted in 1998 when most patients received HAART. Results: Thirty-four (77%) of the patients were intravenous drug users. In 1995, 35 (80%) were receiving antiretroviral therapy, but none had a protease inhibitor. A comparison made between patients in the group with CD4 <250/mm3 (group A) and patients in the group with CD4 >250/mm3 (group B) revealed significantly lower levels of plasma selenium concentrations (p < 0.05). In group A women, zinc was significantly lower than in men of the same group (p < 0.05). On the contrary, selenium plasma concentrations were significantly lower in group A men than in group A women (p < 0.05). No significant differences were noted for other micronutrients. In 1998, when most patients were treated with HAART, differences between the two groups were no more significant, neither for selenium nor for zinc matched with sex. Micronutrient values did not significantly differ between patients with viral load below 5,000 copies/ml and patients with viral load above 5,000 copies/ml. Patients treated with HAART had practically no weight loss. Although patients who did not receive HAART had a good immune status, the mean weight loss was up to 4.6 kg. Conclusions: Selenium and zinc deficiencies are dependent on immune status and sex in HIV/AIDS patients. Other micronutrients do not seem to be influenced by the immune status in these patients. HAART reduces selenium and zinc deficiencies and may help avoid weight loss independently of the CD4 cell count.

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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  1. Nerad JL, Gorbach SL: Nutritional aspects of HIV infection. Infect Dis Clin North Am 1994;8:499–515.
  2. Melchior JC, Goulet O: Nutrition et infection par le VIH. Paris, Masson, 1997, chapt vitamines et oligoéléments, pp 142–151.
  3. Sharkey SJ, Sharkey KA, Sutherland LR, Church DL: Nutritional status and food intake in human immunodeficiency virus infection: GI/HIV study group. J Acquir Immune Defic Syndr 1992;5:1091–1098.

    External Resources

  4. Allavena C, Dousset B, May T, Dubois F, Canton P, Belleville F: Relationship of trace element, immunological markers and HIV1 infection progression. Biol Trace Elem Res 1995;47:133–138.
  5. Dvorkin BM: Selenium deficiency in HIV infection and the acquired immunodeficiency syndrome (AIDS). Chem Biol Interact 1994;91:181–186.
  6. Baum MK, Shor-Posner G, Zhang G, Lai H, Quesada JA, Campa A, Jose-Burbano M, Fletcher MA, Sauberlich H, Page JB: HIV-1 infection in women is associated with severe nutritional deficiencies. J Acquir Immune Defic Syndr Hum Retrovirol 1997;16:272–278.
  7. Baum MK, Shor-Posner G, Lai S, Zhang G, Lai H, Fletcher MA, Sauberlich H, Page JB: High risk of HIV-related mortality is associated with selenium deficiency. J Acquir Immune Defic Syndr Hum Retrovirol 1997;15:370–374.
  8. Constans J, Pellegrin JL, Sergeant C, Simonoff M, Pellegrin I, Fleury H, Leng B, Conri C: Serum selenium predicts outcome in HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol 1995;10:392.
  9. Beach RS, Mantero-Atienza E, Shor-Posner G, Javier JJ, Szapocznik J, Morgan R, Sauberlich HE, Cornwell PE, Eisdorfer C, Baum MK: Specific nutrient abnormalities in asymptomatic HIV-1 infections. J AIDS 1992;6:701–708.
  10. Graham NMH, Sorensen D, Odaka N, Brookmeyer R, Chan D, Willett WC, Morris JS, Saah AJ: Relationship of serum copper and zinc levels to HIV-1 seropositivity and progression to AIDS. J AIDS 1991;4:976–980.
  11. Tang AM, Graham NM, Semba RD, Saah AJ: Association between serum vitamin A and E levels and HIV-1 disease progression. J AIDS 1997;11:613–620.
  12. Semba RD, Farzadegan H, Vlahov D: Vitamin A levels and human immunodeficiency virus load in injection drug users. Clin Diagn Lab Immunol 1997;4:93–95.

    External Resources

  13. Grunfeld C, Kotler DP, Hamadeh R, Tierney A, Wang J, Pierson RN: Hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med 1989;86:27–31.
  14. Semba RD, Caiaffa WT, Graham NM, Cohn S, Vlahov D: Vitamin A deficiency and wasting as predictors of mortality in human immunodeficiency virus-infected injection drug users. J Infect Dis 1995;171:1196–1202.

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