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Vol. 20, No. 3, 2002
Issue release date: 2002
Section title: Proceedings of the 6th International Conference on CRRT
Blood Purif 2002;20:252–261
(DOI:10.1159/000047017)

Acute-on-Chronic Liver Failure: Pathophysiological Basis of Therapeutic Options

Jalan R. · Williams R.
Institute of Hepatology, University College, London Medical School and UCL Hospitals, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Proceedings of the 6th International Conference on CRRT

Published online: 2/27/2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU

Abstract

The vast majority of patients that are referred to a specialist hepatological centre suffer from acute deterioration of their chronic liver disease. Yet, this entity of acute-on-chronic liver failure remains poorly defined. With the emergence of newer liver support strategies, it has become necessary to define this entity, its pathophysiology and the short- and long-term prognosis. This review focusses upon how a precipitant such as an episode of gastrointestinal bleeding or sepsis may start a cascade of events that culminate in end-organ dysfunction and liver failure. We briefly review the pathophysiological basis of the therapeutic modalities that are available. Our current strategy for the management of liver failure involves supportive therapy for the end-organs with the hope that liver function would recover if sufficient time for such a recovery is allowed. Because liver failure, whether of the acute or acute-on-chronic variety, is potentially reversible, the stage is set for the application of newer liver-support strategies to enhance the recovery process.


Article / Publication Details

First-Page Preview
Abstract of Proceedings of the 6th International Conference on CRRT

Published online: 2/27/2002

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 0253-5068 (Print)
eISSN: 1421-9735 (Online)

For additional information: http://www.karger.com/BPU


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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