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Vol. 74, Suppl. 1, 1998
Issue release date: September 1998

Chronic Lung Disease: The Role of Oxidative Stress

Saugstad O.D.
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

References

  1. Saugstad OD: Bronchopulmonary dysplasia and oxidative stress: Are we closer to an understanding of the pathogenesis of BPD? Acta Paediatr 1997;86:1277–1282.

    External Resources

  2. Kari MA, Hallman M, Eronen M, Teramo K, Virtanen M, Koivisto M, Ikonen RS: Prenatal dexamethasone treatment in conjunction with rescue therapy of human surfactant: A randomized placebo-controlled multicenter study. Pediatrics 1994;93:730–736.
  3. Northway WH, Rosan RC, Porter DY: Pulmonary disease following respirator therapy of hyaline-membrane disease. Bronchopulmonary dysplasia. N Engl J Med 1967;276:357–368.
  4. O’Brodovich HM, Mellins RB: Bronchopulmonary dysplasia. Unresolved neonatal acute lung injury. Am Rev Respir Dis 1985;132:694–709.
  5. Saugstad OD: Oxygen toxicity in the neonatal period. Acta Paediatr Scand 1990;79:881–892.
  6. Saugstad OD, Gluck L: Plasma hypoxanthine levels in newborn infants: A specific indicator of hypoxia. J Perinat Med 1982;10:266–272.

    External Resources

  7. Saugstad OD, Hallman M, Abraham J, Cochrane CG, Espstein B, Gluck L: Hypoxanthine and oxygen induced lung injury: A basic mechanism of tissue damage? Pediatr Res 1984;18:501–504.
  8. Saugstad OD: Hypoxanthine as an indicator of hypoxia: Its role in health and disease through free radical production. Pediatr Res 1988;23:143–150.
  9. Frank L, Groseclose EE: Preparation for birth into an O2-rich environment: The antioxidant enzymes in the developing rabbit lung. Pediatr Res 1984;18:240–244.
  10. Yam J, Frank L, Roberts RJ: Age-related development of pulmonary antioxidant enzymes in the rat. Proc Soc Exp Biol Med 1978;157:293–296.

    External Resources

  11. Frank L, Sosenko IR: Prenatal development of lung antioxidant enzymes in four species. J Pediatr 1987;110:106–110.
  12. Tanswell AK, Freeman BA: Pulmonary antioxidant enzyme maturation in the fetal and neonatal rat. I. Developmental profiles. Pediatr Res 1984;18:584–587.
  13. Gerdin E, Tyden O, Erikson UJ: The development of antioxidant enzymatic defense in the perinatal rat lung. Activities of superoxide dismutase, gluthathione peroxidase and catalase. Pediatr Res 1984;19:687–691.
  14. Hayashibe H, Asayama K, Dobashi K, Kato K: Prenatal development of antioxidant enzymes in the rat lung, kidney, and heart: Marked increase in immunoreactivity superoxide dismutase, glutathione peroxidase, and catalase in the kidney. Pediatr Res 1990;27:472–475.
  15. Frank L, Sosenko IRS: Failure of premature rabbits to increase antioxidant enzymes during hyperoxic exposure: Increased susceptibility to pulmonary oxygen toxicity compared with term rabbits. Pediatr Res 1991;29:292–296.
  16. Chen Y, Whitney PL, Frank L: Comparative responses of premature versus full-term newborn rats to prolonged hyperoxia. Pediatr Res 1994;35:233–237.
  17. Phylactos AC, Leaf AA, Costeloe K, Crawford MA: Erythrocyte copper/zinc superoxide dismutase exhibits reduced activity in preterm and low-birthweight infants at birth. Acta Paediatr 1995;84:1421–1425.

    External Resources

  18. Pallardo FV, Sastre J, Asensi M, Rodrigo F, Estrela JM, Vina J: Physiological changes in glutathione metabolism in foetal and newborn rat liver. Biochem J 1991;274:891–893.

    External Resources

  19. Vina J, Vento M, Garcia-Sala F, Puertes IR, Gasco E, Sastre J, Asensi M, Pallardo FV: L-Cysteine and glutathione metabolism are impaired in premature infants due to cystathionase deficiency. Am J Clin Nutr 1995;61:1067–1069.
  20. Saugstad OD: Mechanisms of tissue injury by oxygen radicals: Implications for neonatal disease. Acta Paediatr 1996;85:1–4.

    External Resources

  21. Johnson KJ, Fantone JC, Kaplan J, Ward PA: In vivo damage of rat lungs by oxygen metabolites. J Clin Invest 1981;67:983–993.

    External Resources

  22. Saugstad OD, Hallman M, Becher G, Oddoy A, Lachmann B: Respiratory failure caused by intratracheal saline: Additive effect of xanthine oxidase. Biol Neonate 1988;54:61–67.

    External Resources

  23. Saugstad OD, Becher G, Grossmann M, Merker G, Oddoy A, Lachmann B: Acute and chronic effects of xanthine oxidase on lung thorax-compliance in guinea pigs. Intensive Care Med 1987;13:30–32.

    External Resources

  24. Russell GAB, Cooke RWI: Randomised controlled trial of allopurinol prophylaxis in very preterm infants. Arch Dis Child 1995;73:F27–F31.
  25. Wilborn A, Evers LB, Canada AT: Oxygen toxicity to the developing lung of the mouse: Role of reactive oxygen species. Pediatr Res 1996;40:225–232.

    External Resources

  26. Han RN, Buch S, Tseu I, Young J, Christie NA, Frndova H, Lye SJ, Post M, Tanswell AK: Changes in structure, mechanics, and insulin-like growth factor-related gene expression in the lungs of newborn rats exposed to air or 60% oxygen. Pediatr Res 1996;39:921–929.
  27. Kelly FJ, Lubec G: Hyperoxic injury of immature guinea pig lung is mediated via hydroxyl radicals. Pediatr Res 1995;38:286–291.
  28. Coalson JJ: Experimental models of bronchopulmonary dysplasia. Biol Neonate 1997;71(suppl 1):35–38.
  29. Clerch LB, Wright AE, Coalson JJ: Lung manganese superoxide dismutase protein expression increases in the baboon model of bronchopulmonary dysplasia and is regulated at a posttranscriptional level. Pediatr Res 1996;39:253–258.
  30. Pitkanen OM, Hallman M, Andersson SM: Correlation of free oxygen radical-induced lipid peroxidation with outcome in very low birth weight infants. J Pediatr 1990;116:760–764.
  31. Varsila E, Pitkanen O, Hallman M, Andersson S: Immaturity-dependent free radical activity in premature infants. Pediatr Res 1994;36:55–59.
  32. Varsila E, Hallman M, Andersson S: Free-radical-induced lipid peroxidation during the early neonatal period. Acta Paediatr 1994;83:692–695.

    External Resources

  33. Gladstone IM, Levine RL: Oxidation of proteins in neonatal lungs. Pediatrics 1994;93:764–768.
  34. Varsila E, Pesonen E, Andersson S: Early protein oxidation in the neonatal lung is related to development of chronic lung disease. Acta Paediatr 1995;84:1296–1299.

    External Resources

  35. Ogihara T, Okamoto R, Kim H-S, Nagai A, Morinobu T, Moji H, Kamegai H, Hirano K, Ogihara H, Tamai H, Mino M: New evidence for the involvement of oxygen radicals in triggering neonatal chronic lung disease. Pediatr Res 1996;39:117–119.
  36. Cotton RB, Morrow JD, Hazinski TA, Roberts LJ, Law AB, Steele S: F2-isoprostanes (F2-I) in tracheobronchial aspirate fluid (TBAF) indicate association between increased FiO2 and lipid peroxidation in the lungs of premature infants (abstract). Pediatr Res 1996;39:329.
  37. Lubec G, Widness JA, Hayde M, Menzel D, Pollak A: Hydroxyl radical generation in oxygen-treated infants. Pediatrics 1997;100:700–704.
  38. Babior BM, Kipnes RS, Curnutte JT: Biological defense mechanisms. The production of superoxide: A potential bactericidal agent. J Clin Invest 1973;52:741–744.
  39. Merritt TA, Cochrane CG, Holcomb K, Bohl B, Hallman M, Strayer D, Edwards DK, Gluck L: Elastase and alpha 1-proteinase inhibitor activity in tracheal aspirates during respiratory distress syndrome. Role of inflammation in the pathogenesis of bronchopulmonary dysplasia. J Clin Invest 1983;72:656–666.
  40. Groneck P, Speer CP: Inflammatory mediators and bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed 1995;73:F1–F3.

    External Resources

  41. Groneck P, Gotze-Speer B, Oppermann M, Eiffert H, Speer CP: Association of pulmonary inflammation and increased microvascular permeability during the development of bronchopulmonary dysplasia: A sequential analysis of inflammatory mediators in respiratory fluids of high-risk preterm neonates. Pediatrics 1994;93:712–718.
  42. Ogden B, Murphy S, Saunders G, Pathak D, Johnson J: Neonatal lung neutrophils and elastase/proteinase inhibitor imbalance. Am Rev Respir Dis 1984;130:817–821.
  43. Kojima T, Sasai M, Kobayashi Y: Increased soluble ICAM-1 in tracheal aspirates of infants with bronchopulmonary dysplasia. Lancet 1993;342:1023–1024.
  44. Etzioni A: Adhesion molecules: Their role in health and disease. Pediatr Res 1996;39:191–198.
  45. Fellman V, Raivio KO: Reperfusion injury as a mechanism of brain damage after perinatal asphyxia. Pediatr Res 1997;41:599–606.
  46. Stefano JL, Spear ML, Pearlman SA, Fawcett P, Proujanski R: Soluble Interleukin-2-receptor levels in infants with bronchopulmonary dysplasia. Pediatr Pulmonol 1992;14:58–62.
  47. Moison RM, de Beaufort AJ, Haasnot AA, Dubbelman TM, van Zoeren-Grobben D, Berger HM: Uric acid and ascorbic acid redox ratios in plasma and tracheal aspirate of preterm babies with acute and chronic lung disease. Free Radic Biol Med 1997;23:226–234.

    External Resources

  48. Bracci R: Free oxygen radicals and surfactant. Biol Neonate 1997;71(suppl 1):23–27.
  49. Moison RMW, Palinckx JJS, Roest M, Houdkamp E, Berger HM: Induction of lipid peroxidation of pulmonary surfactant by plasma of preterm babies. Lancet 1993;341:79–82.
  50. Haddad IY, Ischiropoulos H, Holm BA, Beckman JS, Baker JR, Matalon S: Mechanisms of peroxynitrite-induced injury to lung surfactants. Am J Physiol 1993;265:L555–L564.

    External Resources

  51. Hallman M: Molecular interactions between nitric oxide and lung surfactant. Biol Neonate 1997;71(suppl 1):44–48.
  52. Haagsman HP: Oxidative damage of the pulmonary surfactant system. Semin Neonatol 1998, in press.
  53. Beckman JS, Beckman TW, Chen J, Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990;87:1620–1624.
  54. Holm BA, Matalon S, Finkelstein JN, Notter RH: Type II pneumocyte changes during hyperoxic lung injury and recovery. J Appl Physiol 1988;65:2672–2678.
  55. Nogee LM, Wispe JR, Clark JC, Weaver T, Whitsett JA: Increased expression of pulmonary surfactant proteins in oxygen exposed rats. Am J Respir Cell Mol Biol 1991;4:102–107.
  56. Holm BA, Hudak BB, Keicher L, Cavanaugh C, Baker RR, Hu P, Matalon S: Mechanisms of H2O2-mediated injury of type II cell surfactant metabolism and protection with PEG-catalase. Am J Physiol 1991;261:C751–C757.

    External Resources

  57. Novotny WE, Hudak BB, Matalon S, Holm BA: Hyperoxic lung injury reduces exogenous surfactant clearance in vivo. Am J Respir Crit Care Med 1995;151:1843–1847.
  58. Dhar V, Hallman M, Lappalainen U, Bry K: Interleukin-1-alpha upregulates the expression of surfactant protein-A in rabbit lung explants. Biol Neonate 1997;71:46–52.
  59. Nilsson R, Grossmann G, Berggren P, Robertson B: Surfactant treatment in experimental hyaline membrane disease. Eur J Respir Dis 1981;62:441–449.

    External Resources

  60. Robertson B, Berry D, Curstedt T, Grossmann G, Ikegami M, Jacobs H, Jobe A, Jones S: Leakage of protein in the immature rabbit lung: Effect of surfactant replacement. Repsir Physiol 1985;61:265–276.
  61. Chen Y, Sosenko IL, Frank L: Positive regulation of pulmonary antioxidant enzyme gene expression by prenatal thyrotropin releasing hormone plus dexamethasone treatment in premature rats exposed to hyperoxia. Pediatr Res 1995;37:611–616.

    External Resources

  62. Rosenfeld W, Evans H, Concepcion L, Jhaveri R, Schaffer H, Friedman A: Prevention of bronchopulmonary dysplasia by administration of bovine superoxide dismutase in preterm infants with respiratory distress syndrome. J Pediatr 1984;105:781–785.
  63. Davis JM, Rosenfeld WN, Sanders RJ, Gonenne A: Prophylactic effects of recombinant human superoxide dismutase in neonatal lung injury. J Appl Physiol 1993;74:2234–2241.
  64. Davis JM, Rosenfeld WN, Richter SE, Parad RP, Gewolb IH, Spitzer AR, Carlo WA, Couser RJ, Price A, Flaster E, Kassem N, Edwards L, Tierny J, Horowitz S: Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome. Pediatrics 1997;100:24–30.
  65. Shenai JP, Kennedy KA, Stahlman MT: Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia. J Pediatr 1987;111:269–277.
  66. Ehrenkranz RA, Ablow RC, Warshaw JB: Effect of vitamin E on the development of oxygen induced lung injury in neonates. Ann NY Acad Sci 1982;393:452–466.

    External Resources

  67. Watts JL, Milner R, Zipursky A, Paes B, Ling E, Gill G, Fletcher B, Rand C: Failure of supplementation with vitamin E to prevent bronchopulmonary dysplasia in infants less than 1,500 g birth weight. Eur Respir J 1991;4:188–190.


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