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Table of Contents
Vol. 169, No. 3, 2001
Issue release date: 2001
Section title: Paper
Cells Tissues Organs 2001;169:248–256
(DOI:10.1159/000047888)

Degradative Pathways in Tissues of the Temporomandibular Joint

Use of in vitro and in vivo Models to Characterize Matrix Metalloproteinase and Cytokine Activity

Puzas J.E. · Landeau J.-M. · Tallents R. · Albright J. · Schwarz E.M. · Landesberg R.
Departments of aOrthopaedics and bDentistry, University of Rochester School of Medicine and Dentistry, Rochester, N.Y., and cDepartment of Oral and Maxillofacial Surgery, Columbia University School of Dental and Oral Surgery, New York, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/29/2001

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Identification of a small animal model that undergoes pathological temporomandibular joint (TMJ) degeneration would represent a significant research tool. To date however, no such model has been described. We therefore have investigated the pathological and immunohistochemical features of the TMJ of a transgenic mouse that over expresses the human form of TNFα. The TMJ of this animal appears to undergo changes that resemble arthriditics of temporomandibular dysfunction. Furthermore, the disc and articular cells express MMP9 and IL-1. Future work should validate this animal model as one that would have utility for the study of TMJ disorders. Maintenance of connective tissues in joints such as the TMJ is a normal process that allows for the reconstitution of important anatomic features. This maintenance involves both the removal and re-synthesis of structural proteins such as collagens, elastins and proteoglycans. An imbalance in the pathways for degradation and synthesis can lead to the degeneration of joint tissues. We describe the presence of a matrix metalloproteinase, MMP9 (92-kD gelatinase), in TMJ disc and articular cells that likely function in the degradative process. Additionally, we show that this enzyme is under the control of pro-inflammatory cytokines whereby TGFβ and IL-1 stimulate and PGE2 inhibits its activity.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 6/29/2001

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 1

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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